| Name | Tenatoprazole |
| Description | Tenatoprazole (TU-199), a prodrug of the proton pump inhibitor (PPI) class, can inhibit proton transport (IC50: 3.2 μM). |
| In vitro | Tenatoprazole labeled only the gastric H+,K+-ATPase alpha-subunit as has been found for other PPIs, approximately 2.6 nmol/mg of tenatoprazole is bound to the H+,K+-ATPase. The two enantiomers (R)- or (S)-tenatoprazole give the same stoichiometry of binding with 88% inhibition. Tenatoprazole labels only the peptide containing fifth and sixth transmembrane segments, these contain two cysteines, cysteine 813 in the luminal vestibule and cysteine 822 in the sixth transmembrane domain. [1] |
| In vivo | Tenatoprazole provides slow activation in vivo, which is predicted by its chemical activation rate in fasting rats. Tenatoprazole inhibits about 20–30% of enzyme activity even though acid secretion in fasting rats. (S)-tenatoprazole sodium salt hydrate provides a higher Cmax of 183 ng/mL, Tmax of 1.3 hours and AUC of 822 ng*h/mL in dog. [1] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 11 mg/mL (31.76 mM), Sonication is recommended.
Ethanol : 12 mg/mL (34.64 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.77 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | virus | TU199 | TU 199 | Tsg101 | Tenatoprazole | secretion | Protonpump | Proton Pump | oral | Inhibitor | inhibit | gastric | ATPase | acid |
| Inhibitors Related | Abscisic Acid | Rabeprazole Sulfide | Omeprazole | Chebulinic acid | Esomeprazole | Pantoprazole sodium | Esomeprazole Magnesium | Pantoprazole Sodium Hydrate | Vonoprazan Fumarate | Lansoprazole | Zinc pyrithione | Esomeprazole Sodium |
| Related Compound Libraries | Target-Focused Phenotypic Screening Library | Exosome Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Viral Compound Library | Inhibitor Library | Orally Active Compound Library | PPI Inhibitor Library | Bioactive Compounds Library Max | Anti-Infection Compound Library | Anti-Cancer Compound Library | Human Metabolite Library |
United States
