| Name | Tenidap |
| Description | Tenidap (CP-66248) is a selective COX-1 and SLC26A3 inhibitor with anti-inflammatory, analgesic, and anti-rheumatic activities. |
| In vitro | The human astrocytoma cell line U373 MG was incubated with 0.1-100 µM tenidap for 30 min and then stimulated with 50 µM C6-ceramide for 24 h. Tenidap inhibited the dose-dependent ceramide-induced IL-6 protein synthesis in U373 human astrocytoma cells.[4] |
| In vivo | After sustained epilepsy (SE) induced by trichostatin in male Wistar rats, Tenidap was administered at 10 mg / kg daily for 10 days, 46.88 ± 10.70 neurons survived in the tenidap-SE group, and 37.75 ± 8.78 neurons survived in the tenidap-SE group, Tenidap significantly inhibited the hippocampal expression of COX-2 in the hippocampus, especially in the CA3 region.[3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 20 mg/mL (62.35 mM), Sonication is recommended.
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| Keywords | Tenidap | RNASynthesis | RNA Synthesis | DNASynthesis | DNA Synthesis | CP66248 | CP 66248 | COX-2 | COX-1 |
| Inhibitors Related | 5-Fluorouracil | Acetaminophen | Guanidine hydrochloride | Hexane-1,6-diol | 1,4-Naphthoquinone | Adenine | Carbazole | Indomethacin | Thymidine | Trometamol | Usnic Acid | Magnesium sulfate |
| Related Compound Libraries | Nonsteroidal Anti-Inflammatory Compound Library | Pain-Related Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | HIF-1 Signaling Pathway Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Human Metabolite Library | Anti-Cancer Drug Library |
United States
