| Name | Tenofovir alafenamide |
| Description | Tenofovir alafenamide (GS-7340) is a nucleotide reverse transcriptase inhibitor (NRTI) and a novel ester prodrug of the antiretroviral tenofovir. |
| In vitro | Tenofovir alafenamide has a potent anti-HIV activity with IC50 of 0.005 μM. [1] GS 7340 has a half-life of 90 min in human plasma and a half-life of 28.3 min in an MT-2 cell extract at 37°C. [2] the hepatic uptake of Tenofovir alafenamide isfacilitated by OATP1B1 and OATP1B3, respectively. Tenofovir alafenamide inhibits HBV reverse transcriptase after being converted to the pharmacologically active form, TFV-DP. [3] |
| In vivo | In male beagle dogs, GS 7340 (10 mg/kg, p.o.) results in an enhanced distribution to lymphatic tissue. [2] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 70 mg/mL (146.91 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : 88 mg/mL (184.69 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.2 mM), Sonication is recommended.
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| Keywords | Tenofovir alafenamide | ReverseTranscriptase | Reverse Transcriptase | Inhibitor | inhibit | Human immunodeficiency virus | HIVProtease | HIV Protease | HIV | GS7340 | GS 7340 |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Emtricitabine | Dolutegravir intermediate-1 | Dimethyl fumarate | Lamivudine | Chloroquine phosphate | Valproic Acid | (-)-Epigallocatechin Gallate | Decanedioic acid | Dextran sulfate sodium salt (MW 5000) | Tenofovir |
| Related Compound Libraries | Bioactive Compound Library | Approved Drug Library | ReFRAME Related Library | EMA Approved Drug Library | Anti-Viral Compound Library | Drug Repurposing Compound Library | Inhibitor Library | FDA-Approved Drug Library | Orally Active Compound Library | Bitter Compound library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |
United States
