| Name | Tenovin-6 Hydrochloride |
| Description | Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator . |
| In vitro | Inhibition of SIRT1/2 by Tenovin-6 induced apoptosis in UM cells by activating the expression of tumor suppressor genes such as p53 and elevating reactive oxygen species (ROS).?Tenovin-6 inhibited the growth of UM cells.?Tenovin-6 and vinblastine was synergistic in inducing apoptosis of UM cell line 92.1 and Mel 270.?Furthermore, Tenovin-6 eliminated cancer stem cells in 92.1 and Mel 270 cells.?In conclusion, our findings suggest that Tenovin-6 may be a promising agent to kill UM bulk tumor cells and CSCs[1].tenovin-6 increases microtubule-associated protein 1 light chain 3 (LC3-II) level in diverse cell types in a time- and dose-dependent manner. Mechanistically, the increase of LC3-II by tenovin-6 is caused by inhibition of the classical autophagy pathway via impairing lysosomal function without affecting the fusion between autophagosomes and lysosomes.tenovin-6 activation of p53 is cell type dependent, and tenovin-6 inhibition of autophagy is not dependent on its regulatory functions on p53 and SIRT1[2]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 45 mg/mL (91.63 mM), Sonication is recommended.
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| Keywords | Tenovin-6 Hydrochloride | Tenovin6 Hydrochloride | Tenovin-6 | Tenovin6 | Tenovin 6 Hydrochloride | Tenovin 6 | Sirtuin | SIRT3 | SIRT2 | SIRT1 | protein-deacetylating | p53 | MDM-2/p53 | MDM2 | Inhibitor | inhibit | HDAC8 | Dihydroorotate Dehydrogenase | DHODH | degradation | Autophagy | acetylation |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Nicotinamide riboside malate | Tamoxifen | Guanidine hydrochloride | Hydroxychloroquine | Manganese chloride (tetrahydrate) | Paeonol | Naringin | Alginic acid | Sildenafil citrate |
| Related Compound Libraries | Ferroptosis Compound Library | Mitochondrial Membrane Protein-Targeted Compound Library | Bioactive Compound Library | Endoplasmic Reticulum Stress Compound Library | Ubiquitination Compound Library | Epigenetics Compound Library | Hematonosis Compound Library | Pyroptosis Compound Library | Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Transcription Factor-Targeted Compound Library |
United States
