| Name | Tetracycline |
| Description | Tetracycline is an orally active broad-spectrum antibiotic that exhibits inhibitory activity against various Gram-positive and Gram-negative bacteria, as well as Chlamydia, Mycoplasma, and Rickettsia. It is commonly used in anti-infection research and can also be used to induce tumor regression based on BCR-ABL gene silencing. |
| In vitro | METHODS: Neuroblastoma cells were treated with Binimetinib (0-2 µM) for 24-120 h. Cell viability was measured by MTT assay.
RESULTS: Four cell lines, CHP-212, SK-N-BE, SK-N-AS and SJ-NB-10, were sensitive to Binimetinib, achieving <50% survival after 24-120 h of treatment, while five cell lines were resistant to the drug. [1]
METHODS: NSCLC cells A549, H157 and H522 were treated with Binimetinib (0.5-1 µM) for 48 h. Cell cycle was measured by flow cytometry.
RESULTS: Binimetinib induced G1 phase block in three sensitive NSCLC cell lines at relatively low concentration ranges, e.g. 0.5 and 1 µM. [2] |
| In vivo | METHODS: To detect in vivo antitumor activity, Binimetinib (5 mg/kg) and BMK120 (7.5 mg/kg) were administered by gavage to athymic (nu/nu) mice bearing A549 xenografts once daily for 21 days.
RESULTS: Binimetinib and BKM120 alone at the doses tested only weakly inhibited the growth of A549 xenografts, but the combination of Binimetinib and BKM120 significantly inhibited the growth of A549 xenografts. [2] |
| Storage | Powder: -20°C for 3 years
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 15 mg/mL (33.75 mM), Solution.
DMSO : 262.5 mg/mL (590.64 mM), Sonication is recommended.
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| Keywords | Tetracycline | oral | Major prion protein | Inhibitor | inhibit | broad-spectrum | Bacterial | Antibiotic | 30S ribosome | 16S ribosome |
| Inhibitors Related | Neomycin sulfate | Adipic dihydrazide | Levulinic acid | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Doxycycline | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate | BES |
United States
