Use of Tetraphenylporphyrin Tetrasulfonic Acid Hydrate
TPPS can be used as a non-cytotoxic probe for detecting tumor location[1].
Properties
Articles30
Spectrum
Names
Name
tpps
Synonym
More Synonyms
Biological Activity
Description
TPPS can be used as a non-cytotoxic probe for detecting tumor location[1].
Related Catalog
Research Areas >> Cancer
Signaling Pathways >> Others >> Others
In Vitro
TPPS (0-20 μg/mL) shows no toxicity in Vero and HEp-2 cells in vitro and predominantly locates in the soluble and protein fractions in cells[1].
In Vivo
TPPS4 shows the highest tumor to tissue ratios after 96 hours injection with a dose dependent manner[2]. TPPS4 appears to be cleared through the kidneys and absolute concentrations there are reduced with increasing time after injection[2].
References
[1]. Austen JD, et al. Intracellular localization of meso-Tetra(p-sulfophenyl)porphine: a potential tumor localizing agent. Cancer Treat Rep. 1978 Apr;62(4):511-8.
[2]. https://pubmed.ncbi.nlm.nih.gov/201378/
Chemical & Physical Properties
Density
1.6±0.1 g/cm3
Molecular Formula
C44H30N4O12S4
Molecular Weight
934.989
Exact Mass
934.074280
PSA
307.30000
LogP
5.01
Index of Refraction
1.724
MSDS
MSDS(Chinese)
Safety Information
Symbol
GHS07
Signal Word
Warning
Hazard Statements
H315-H319-H335
Precautionary Statements
P261-P305 + P351 + P338
Personal Protective Equipment
dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes
Xi
Risk Phrases
R36/37/38
Safety Phrases
S26
RIDADR
NONH for all modes of transport
WGK Germany
3
RTECS
DB7339000
Synthetic Route
Total: 1 Page
tetraphenylporphyrin
CAS#:917-23-7
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Tetraphenylporp...
CAS#:35218-75-8
Literature: Journal of the Chemical Society, Faraday Transactions, , vol. 89, # 3 p. 495 - 502
tetra(4-fluoros...
CAS#:88289-00-3
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Tetraphenylporp...
CAS#:35218-75-8
Literature: Journal of Organic Chemistry USSR (English Translation), , vol. 28, # 12.1 p. 1987 - 1994 Zhurnal Organicheskoi Khimii, , vol. 28, # 12 p. 2464 - 2472
Articles30
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Femtosecond to second studies of a water-soluble porphyrin derivative in chemical and biological nanocavities.
Langmuir 28(9) , 4363-72, (2012)
The interactions of 5,10,15,20-tetrakis(4-sulfonatophenyl)-porphyrin (TSPP) with a quaternary ammonium modified β-cyclodextrin (QA-β-CD) and human serum albumin (HSA) protein in aqueous solutions at p...
Preferential solvation and solvation shell composition of free base and protonated 5, 10, 15, 20-tetrakis(4-sulfonatophenyl)porphyrin in aqueous organic mixed solvents.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 83(1) , 213-20, (2011)
The solvatochromic properties of the free base and the protonated 5, 10, 15, 20-tetrakis(4-sulfonatophenyl)porphyrin (TPPS) were studied in pure water, methanol, ethanol (protic solvents), dimethylsul...
Interaction of monosulfonate tetraphenyl porphyrin (H2TPPS1) with plant-esterase: determination of the binding mechanism by spectroscopic methods.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 78(5) , 1349-55, (2011)
The interaction of monosulfonate tetraphenyl porphyrin (H(2)TPPS(1)) with plant-esterase was investigated using fluorescence and UV-vis absorption spectroscopy. Fluorescence quenching, from which the ..
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