| Name | Thiabendazole |
| Description | Thiabendazole (2-(4-Thiazolyl)benzimidazole) is a benzimidazole derivative with anthelminthic property. |
| In vitro | Thiabendazole provokes a strong DNA-damaging activity in the human lymphoblastoid cell line that constitutively expresses human CYP1A1 cDNA, but not in the parental line, indicating that CYP1A1 is chiefly implicated in carbaryl and thiabendazole genotoxicity. [1] Thiabendazole provokes a dose- and time-dependent increase in CYP1A1 (EROD activity, protein and mRNA levels) in primary culture of rat hepatocytes. [2] Thiabendazole results in the induction of 7-ethoxyresorufin O-deethylase and 7-pentoxyresorufin O-depentylase activities, CYP1A1, CYP1A2, CYP2B1 and CYP2B1/2 mRNA levels and CYP1A2 and CYP2B1/2 apoprotein levels. Thiabendazole markedly induces GSTP1 mRNA levels, but has only a small effect on GSTT1 mRNA levels. [3] Thiabendazole is rapidly transported by passive diffusion through the human intestinal cells by comparison with the protein-bound residues which are not able to cross the intestinal barrier. Thiabendazole will be firstly metabolized to 5OH-TBZ and subsequently converted to a chemically reactive metabolic intermediate binding to proteins. [4] |
| In vivo | Thiabendazole results in nephrosis or hydronephrosis and this organ toxicity may lead to the high dose-dependent mortality in treated mice. Thiabendazole results in hormone imbalance and this imbalance may play an important role in the changes of the reproductive or endocrine system in treated mice. [5] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : 1 mg/mL (4.97 mM), Sonication is recommended.
DMSO : 50 mg/mL (248.45 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (4.97 mM), Sonication is recommended.
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| Keywords | Tubulin β | Thiabendazole | Parasite | MitochondrialMetabolism | Mitochondrial Metabolism | MicrotubuleAssociated | Microtubule Associated | Inhibitor | inhibit |
| Inhibitors Related | Kaolin | 2-Chloropyrazine | Gum arabic | D(+)-Raffinose pentahydrate | Hydroxychloroquine | Metronidazole | Hydroxypropyl Cellulose | 2-Amino-2-methyl-1-propanol | Doxycycline | Fenpyroximate | Gluconate Calcium | Sodium Molybdate |
| Related Compound Libraries | Pesticide Compound Library | Anti-Parasitic Compound Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Anti-Fungal Compound Library | Drug Repurposing Compound Library | Microtubule-Targeted Compound Library | Tobacco Monomer Library | FDA-Approved Kinase Inhibitor Library | FDA-Approved Drug Library | Cosmetic Ingredient Compound Library | Anti-Aging Compound Library |
United States
