| Name | Thiamine hydrochloride |
| Description | Thiamine hydrochloride (Vitamin B1) is an essential micronutrient and a cofactor for many central metabolic enzymes. |
| In vitro | METHODS: SK-N-BE cells (neuroblastoma cells) and Panc-1 cells (pancreatic cancer cells) were treated with Thiamine hydrochloride (10-5-102 mM) for 5 days, and the cell growth inhibition was detected by crystal violet assay.
RESULTS: Thiamine hydrochloride inhibited the growth of SK-N-BE cells (IC50=4.9 mM) and Panc-1 cells (IC50=5.4 mM). [1] |
| In vivo | METHODS: To investigate the effect of Thiamine hydrochloride on memory, Thiamine hydrochloride (300 µg/kg) was administered to adult mice with scopolamine-induced memory dysfunction every other day for the last 14 days of the experiment.
RESULTS: Thiamine hydrochloride improved memory dysfunction in mice through Nrf-2/TLR4 signaling pathway. [2]
METHODS: To study the anti-inflammatory and anti-hyperalgesia effects of Thiamine hydrochloride, Thiamine hydrochloride (150-200 mg/kg) was administered intraperitoneally to Wistar rats with adjuvant-induced arthritis for 21 days.
RESULTS: Thiamine hydrochloride showed anti-inflammatory and anti-hyperalgesia effects. [3]
METHODS: To study the anti-inflammatory activity of Thiamine hydrochloride, Thiamine hydrochloride (20 mg/kg) was administered intraperitoneally to rats with colitis for 5 days.
RESULTS: Thiamine hydrochloride attenuated macroscopic parameters and the summary colitis index in colitis rats. [4] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 95 mg/mL (281.67 mM), Sonication is recommended.
DMSO : 3.37 mg/mL (9.99 mM), Sonication is recommended.
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| Keywords | Vitamin B-1 | Vitamin B 1 | VB1 | Thiamine chloride | Thiamine | HBV | EndogenousMetabolite | Endogenous Metabolite | Apoptosis |
| Inhibitors Related | Sucrose | Neomycin sulfate | Aceglutamide | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Ethyl linoleate | Malic acid | Glycerol | Thymidine | Gluconate Calcium | Dimethyl sulfoxide | Sodium bicarbonate |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Miao medicine Compound Library | Anti-Viral Compound Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Bitter Compound library | Anti-infective Natural Product Library | Flavor Natural Product library | Bioactive Compounds Library Max | Gut Microbial Metabolite Library |
United States
