| Name | Thiethylperazine |
| Description | Thiethylperazine (Tietilperazina) is an orally available, highly potent D2 receptor and H1 receptor antagonist and selective ABCC1 activator with antimicrobial and antiemetic activity that reduces amyloid β (Aβ) load in mice, is used to relieve vertigo, and can be used in studies of neurological diseases such as Alzheimer's disease and Parkinson's disease. Alzheimer's and Parkinson's diseases. |
| In vitro | Thiethylperazine enhances the activity of the antibiotic vancomycin at concentrations as low as 2 μg/mL, and it inhibits vancomycin-sensitive and -resistant Enterococcus strains with MIC values of 8 μg/mL, 16 μg/mL, and 8 μg/mL, respectively[3]. |
| In vivo | Thiethylperazine (3 mg/kg; intramuscular injection; twice daily; for 30 days) markedly decreases Aβ42 levels in young APP/PS1 mice, utilizing an animal model comprising young mice genetically modified to express the amyloid precursor protein (APPswe) and mutant presenilin-1 (PS1) [2], demonstrating a significant reduction in Aβ42 levels and offering insights into potential therapeutic approaches for Alzheimer's disease. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (200.19 mM), Sonication is recommended.
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| Keywords | βAmyloid | β Amyloid | HistamineReceptor | Histamine Receptor | H1 Receptor | DopamineReceptor | Dopamine Receptor | D2 | BetaAmyloid | Beta Amyloid | bAmyloid | b Amyloid | Aβ | ABCC |
| Inhibitors Related | Neomycin sulfate | Levulinic acid | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Doxycycline | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate | Alginic acid | BES |
| Related Compound Libraries | Histamine & Melatonin Receptor-Targeted Compound Library | Bioactive Compound Library | Anti-Alzheimer's Disease Compound Library | Approved Drug Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Anti-Bacterial Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Infection Compound Library |
United States
