| Name | Thiomyristoyl |
| Description | Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM. |
| Cell Research | Human MCF-7 cells are grown in DMEM media contained 10% (vol/vol) heat-inactivated fetal bovine serum and 1% penicillin-streptomycin and treated with in the presence of 200 nM TSA for 6 hr. The acetylation level of p53 protein is determined by western blot using anti-acetyl-p53 (K382) antibody. β-actin serves as a loading control. (Only for Reference) |
| In vitro | In a breast cancer mouse model, Thiomyristoyl inhibits SIRT2 and tumor growth, while also reducing the levels of the c-Myc protein. The anticancer effects of Thiomyristoyl are positively correlated with the reduction of c-Myc levels. |
| In vivo | Thiomyristoyl exhibits weak inhibition towards SIRT3/5/6/7. It can reduce the level of c-MYC in cancer cells in vitro, with the extent of c-MYC reduction directly proportional to the cell line’s sensitivity to Thiomyristoyl. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 100 mg/mL (171.87 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (6.87 mM), Sonication is recommended.
Chloroform : Soluble
H2O : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | Thiomyristoyl | Sirtuin | SIRT2 | SIRT1 | Inhibitor | inhibit |
| Inhibitors Related | JGB1741 | Nicotinamide riboside malate | Sirtinol | Selisistat | MDL-800 | Dihydrocoumarin | SRT 2104 | Nicotinamide riboside | MC3482 | Fisetin | SIRT5 inhibitor 8 | Nicotinamide |
| Related Compound Libraries | Highly Selective Inhibitor Library | Histone Modification Compound Library | Reprogramming Compound Library | Bioactive Compound Library | Endoplasmic Reticulum Stress Compound Library | Chromatin Modification Compound Library | Glutamine Metabolism Compound Library | Antioxidant Compound Library | Inhibitor Library | Mitochondria-Targeted Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max |
United States
