| Name | THIQ |
| Description | THIQ is a selective melanocortin-4 receptor (MC4R) agonist (hMC4R and rMC4R with IC50 of 1.2 nM and 0.6 nM , respectively). |
| In vitro | THIQ,?a small molecule agonist of the MC4R, on the cell surface expression and signaling of ten intracellularly retained MC4R mutants using different cell lines.?THIQ increased the cell surface expression of three mutants (N62S, C84R, and C271Y) and two of them (N62S and C84R) had increased signaling in HEK293 cells.THIQ increased the signaling of two other mutants (P78L and P260Q) without increasing their cell surface expression in HEK293 cells.?In neuronal cells, THIQ exhibited a more potent effect, correcting the cell surface expression and signaling of seven mutants (N62S, I69R, P78L, C84R, W174C, P260Q, and C271Y). |
| Storage | Store at low temperature | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (8.49 mM), Sonication is recommended.
DMSO : 245 mg/mL (415.84 mM), Sonication is recommended.
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| Keywords | THIQ | selective | mutant | MelanocortinReceptor | melanocortin-4 receptor (MC4R) | Melanocortin Receptor | melanocortin | MC Receptor | Inhibitor | inhibit | erectile | eliciting | affinity | activity |
| Inhibitors Related | (±)-Eriodictyol | α-MSH | 4-Methyl-6-Methoxycoumarin | Fenoprofen Calcium | α-MSH acetate | Afamelanotide acetate | BMS-470539 dihydrochloride | ACTH (1-17) acetate | Tetracosactide acetate | [D-Trp8]-γ-MSH acetate(321351-81-9 free base) | 2-MNG | Undecylenoyl phenylalanine |
| Related Compound Libraries | Anti-Obesity Compound Library | NO PAINS Compound Library |
United States
