| Name | Tolmetin sodium dihydrate |
| Description | Tolmetin sodium dihydrate is a potent non-steroidal anti-inflammatory drug (NSAID) that acts as an orally active cyclooxygenase (COX) inhibitor. Tolmetin sodium dihydrate demonstrates inhibitory concentration (IC50) values of 0.35 μM and 0.82 μM for human COX-1 and COX-2 enzymes, respectively, and is widely used as a reference compound for studying the biochemical and pharmacodynamic properties of NSAID-mediated prostaglandin synthesis inhibition. |
| In vitro | Tolmetin sodium dihydrate (0.25 mM) showed no inhibitory effect on lipid peroxidation in rat brain homogenates [3].
Tolmetin sodium dihydrate (0.001-100 μM) exhibited dose-dependent anticancer activity against HT-29 colon carcinoma cells [4].
Tolmetin sodium dihydrate (0-100 μM) had no significant effect on osteoblast growth [5]. |
| In vivo | In male Wistar rats, the ulcerogenic effect of Tolmetin sodium dihydrate (30, 100 mg/kg, oral administration) reached its peak 4 hours after a single dose, while this effect significantly weakened after repeated administration for 3 and 14 days [2]. Pretreatment with Tolmetin sodium dihydrate (5 mg/kg, twice daily) for 5 consecutive days effectively alleviated quinolinic acid (QA)-induced neurotoxicity [3]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 10 mg/mL (31.72 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween-80+45% Saline : 1 mg/mL (3.17 mM), Sonication is recommended.
H2O : ≥ 80 mg/mL, Sonication is recommended.
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| Keywords | Tolmetin (sodium salt hydrate) |
| Inhibitors Related | Naproxen sodium | Acetaminophen | Phenidone | 4-Aminosalicylic acid | Gallic Acid Monohydrate | Diclofenac Potassium | Indomethacin | Paradol | Trometamol | 5-Methylfurfural | Phenylbutazone | Magnesium sulfate |
| Related Compound Libraries | Bioactive Compound Library | Approved Drug Library | Neuronal Signaling Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |
United States
