| Name | Tolterodine tartrate |
| Description | Tolterodine tartrate (PNU-200583E) is a potent antagonist for muscarinic receptor. It show selectivity for the urinary bladder and salivary glands in vivo. |
| In vitro | Tolterodine is a novel muscarinic receptor antagonist for the treatment of symptoms such as overactive bladder and urge incontinence.Tolterodine effectively and competitively inhibited carbamylcholine-induced contractions in guinea pig bladder isolation strips in a concentration-dependent manner.Tolterodine has a high affinity for muscarinic receptors, and its Ki values were 2.7 nM, 1.6 nM, 0.75 nM, 4.8 nM, and 3.3 nM in the bladder, heart,, cortex and human bladder in guinea pigs, respectively. The Ki values of Tolterodine in guinea pig bladder, heart, cerebral cortex, parotid gland and human bladder were 2.7 nM, 1.6 nM, 0.75 nM, 4.8 nM and 3.3 nM, respectively. |
| In vivo | Tolterodine is a novel muscarinic receptor antagonist for the treatment of symptoms such as overactive bladder and urge incontinence.Tolterodine effectively and competitively inhibited carbamylcholine-induced contractions in guinea pig bladder isolation strips in a concentration-dependent manner.Tolterodine has a high affinity for muscarinic receptors, and its Ki values were 2.7 nM, 1.6 nM, 0.75 nM, 4.8 nM, and 3.3 nM in the bladder, heart,, cortex and human bladder in guinea pigs, respectively. The Ki values of Tolterodine in guinea pig bladder, heart, cerebral cortex, parotid gland and human bladder were 2.7 nM, 1.6 nM, 0.75 nM, 4.8 nM and 3.3 nM, respectively. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (6.94 mM), Sonication is recommended.
Ethanol : 6 mg/mL (12.62 mM), Sonication is recommended.
H2O : 14 mg/mL (29.44 mM), Sonication is recommended.
DMSO : 88 mg/mL (185.04 mM), Sonication is recommended.
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| Keywords | urinary | Tolterodine tartrate | Tolterodine | salivary | receptor | Muscarinic acetylcholine receptor | muscarinic | mAChR | Kabi2234 | Kabi 2234 | Inhibitor | inhibit | glands | bladder |
| Inhibitors Related | Adiphenine hydrochloride | Levamisole hydrochloride | Ethyl (triphenylphosphoranylidene) acetate | Urethane | Hexamethonium Bromide | Ribavirin | Adenine | Mitotane | Choline chloride | Propoxur | N,N-Dicyclohexylcarbodiimide | Arecoline |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Failed Clinical Trials Compound Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Toxic Compound Library | Drug Repurposing Compound Library | Inhibitor Library | FDA-Approved Drug Library | Bioactive Compounds Library Max | NMPA-Approved Drug Library |
United States
