| Name | Trachelogenin |
| Description | Trachelogenin ((-)-Trachelogenin), isolated from Combretum fruticosum, is an HCV entry inhibitor with anti-proliferative effects. Its mechanism is related to affecting the phosphorylation of key proteins such as β-Catenin, c-Myc and GSK3 in the β-Catenin signaling pathway. chemical and concentration-dependent. Trachelogenin has antiviral, anti-inflammatory and analgesic activities with IC50 of 0.325 and 0.259 μg/mL in HCVcc and HCVpp models, respectively. |
| In vitro | Trachelogenin is an infection and HCVpp cell entry in a dose-dependent manner with an IC50 of 0.325 and 0.259 μg/mL in HCVcc and HCVpp models, respectively. Trachelogenin exhibits effective antiviral, anti-inflammatory, and analgesic effects.[1] |
| Storage | Store at low temperature | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 77.68 mg/mL (199.99 mM), Sonication is recommended.
10% DMSO+90% Corn Oil : 3.3 mg/mL (8.5 mM), Sonication is recommended.
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| Keywords | β-catenin | βcatenin | Wnt/β-catenin | Wnt/betacatenin | Wnt/b-catenin | Wnt | VirusProtease | Virus Protease | Trachelogenin | HCVProtease | HCV Protease | HCV | c-Myc | cMyc | beta-catenin | betacatenin | bcatenin |
| Inhibitors Related | Rifampicin | Urea | Phenytoin sodium | Methyl 2-amino-5-bromobenzoate | Sofosbuvir | L-Lysine | L-Lysine hydrochloride | Neohesperidin | Ethyl linoleate | Ofloxacin | Vidarabine | Thymidine |
| Related Compound Libraries | Traditional Chinese Medicine Monomer Library | Membrane Protein-targeted Compound Library | Anti-Viral Compound Library | Saccharide and Glycoside Natural Product Library | Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Inhibitor Library | Natural Product Library for HTS | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-virus Traditional Chinese Medicine Monomer Library | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library |
United States
