| Name | Triclocarban |
| Description | Triclocarban (Cutisan), an antimicrobial agent, is used in personal cleaning products. |
| In vitro | Triclocarban (300 nM) enhances the cytotoxicity of 300 μM H2O2 in rat thymocytes without independently increasing cell death, facilitating H2O2-induced cell death and hence elevating the dead cell population [1]. It exhibits estrogenic activities by inducing luciferase in an ER reporter assay, promoting MCF-7 cell proliferation, up-regulating pS2, and down-regulating ERα at mRNA and protein levels in MCF-7 cells [2]. |
| In vivo | Triclocarban, when used in soap during showering, is significantly absorbed by humans, with its peak concentration (Cmax) in whole blood ranging between 23 nM and 530 nM[1]. While exposure to triclocarban during pregnancy does not impact the viability of pregnancy, exposure during lactation adversely affects offspring survival[3]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Corn Oil : 2 mg/mL (6.34 mM), Sonication is recommended.
DMSO : 45 mg/mL (142.59 mM), Sonication is recommended.
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| Keywords | Triclocarban | products | personal | Inhibitor | inhibit | endocrine-disrupting | cleaning | Bacterial | antimicrobial |
| Inhibitors Related | Neomycin sulfate | Adipic dihydrazide | Levulinic acid | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Doxycycline | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate | BES |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | Pain-Related Compound Library | Approved Drug Library | ReFRAME Related Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Anti-Bacterial Compound Library | Cosmetic Ingredient Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Anti-Infection Compound Library |
United States
