| Name | Trolox |
| Description | Trolox is a vitamin E analogue, used in reducing oxidative stress or damage. |
| In vitro | METHODS: Human cervical cancer cells HeLa were treated with Trolox (2.5-160 µM) for 24 h and cell viability was measured using MTT assay.
RESULTS: Cell viability decreased dose-dependently, with the maximum effect observed at 160 µM Trolox. [1]
METHODS: Human skin fibroblasts were treated with Trolox (0.5 mM) for 96 h. The expression levels of target proteins were measured by Western Blot.
RESULTS: Trolox increased the mitochondrial levels of Mfn2 in primary human skin fibroblasts without affecting these levels of Drp1 and hFis1. [2] |
| In vivo | METHODS: To investigate the neuroprotective effects, Trolox (50 mg/kg) was intraperitoneally injected once a day for ten days into an MPTP-induced Parkinson's disease mouse model.
RESULTS: Trolox may exert neuroprotective effects on dopaminergic neurons against MPTP-induced oxidative stress, neuroinflammation, motor dysfunction and neurodegeneration. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (19.98 mM), Solution.
DMSO : 50 mg/mL (199.77 mM), Sonication is recommended.
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| Keywords | Trolox | ReactiveOxygenSpecies | Reactive Oxygen Species | Inhibitor | inhibit | Ferroptosis | Apoptosis | Antioxidant |
| Inhibitors Related | Ethoxyquin | Kaolin | Stavudine | Aceglutamide | Allopurinol | Hemin | Urea | Tamoxifen | Metronidazole | Ethyl linoleate | Formamide | Alginic acid |
| Related Compound Libraries | Ferroptosis Compound Library | Bioactive Compound Library | Antidepressant Compound Library | Anti-Breast Cancer Compound Library | Pyroptosis Compound Library | Inhibitor Library | NO PAINS Compound Library | Anti-Fibrosis Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library |
United States
