| Name | TRPM8 antagonist 2 |
| Description | TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist with an IC50 of 0.2 nM, used in the research of neuropathic pain syndromes. |
| In vitro | TRPM8 antagonist 2 (Compound 14) is a potent and selective TRPM8 antagonist with an IC50 of 0.2 nM, used in neuropathic pain research. It effectively inhibits menthol-induced increases in intracellular Ca2+ levels in Ca2+ fluorimetric assays in HEK293 cells expressing the rat TRPM8 isoform (IC50, 40 nM). |
| In vivo | TRPM8 antagonist 2, administered subcutaneously at doses of 1, 10, and 30 mg/kg, demonstrates significant, dose-dependent antinociceptive effects and reduces wet-dog shakes (WDS)-like cold hypersensitivity in mice by 63% at the 30 mg/kg dosage. Additionally, at lower doses of 0.1 and 1 μg, it effectively mitigates Oxaliplatin (OXP)-induced cold allodynia in mice. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (10.04 mM), Sonication is recommended.
DMSO : 160 mg/mL (401.51 mM), Sonication is recommended.
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| Keywords | TRPVChannel | TRPV Channel | TRPM-8 antagonist 2 | TRPM8 antagonist 2 | TRPM8 | TRPChannel | TRP Channel | Transient receptor potential channels | Inhibitor | inhibit |
| Inhibitors Related | (+)-Camphor | Rosiglitazone | Caffeic Acid | Oleoyl Serotonin | (-)-Menthol | Camphor | Probenecid | Pregnenolone | Nonivamide | 1,4-Cineole | trans-Cinnamaldehyde | Methyl salicylate |
| Related Compound Libraries | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | Pain-Related Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Compound Library |
United States
