| Name | Tyrphostin 8 |
| Description | Tyrphostin 8(4-Hydroxybenzylidenemalononitrile) is a potent GTPase inhibitor that inhibits EGFR kinase with an IC50 of 560 μM.Tyrphostin 8 inhibits protein serine/threonine calmodulin phosphatases (IC50=21 μM), enhances transferrin receptor-mediated transcytosis in Caco-2 cells, and increases the hypoglycemic effect of oral insulin-transferrin. hypoglycemic effect. |
| In vitro | Pretreated for 20 minutes at concentrations ranging from 10 to 100 μM, Tyrphostin 8 blocks Carbachol-initiated PKCδ tyrosine phosphorylation and ERK1/2 activation in parotid acinar cells[1]. Additionally, at concentrations of 10-100 μM, Tyrphostin 8 induces a rapid and substantial increase in the basal O2 consumption of parotid acinar cells[1]. Furthermore, at a concentration of 100 μM, Tyrphostin 8 reduces parotid ATP content by approximately 90%[1]. In another context, Tyrphostin 8 enhances the apical-to-basolateral transport of insulin-transferrin conjugate by promoting transferrin receptor-mediated transcytosis in filter-grown Caco-2 cell monolayers[2]. |
| In vivo | In Streptozotocin-induced diabetic rats, Tyrphostin 8 enhances the glucose-lowering effect of insulin-transferrin[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (293.82 mM), Sonication is recommended.
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| Keywords | Tyrphostin 8 | GTPase | EGFR |
| Inhibitors Related | RMC-9805 | β-Glycerophosphate disodium salt pentahydrate | Hexane-1,6-diol | Cyclosporine | Erlotinib | Tartaric acid disodium dihydrate | Sotorasib | Stearic acid | L-Ascorbic acid 2-phosphate magnesium | Daraxonrasib | Gefitinib | β-Glycerophosphate disodium salt hydrate |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Diabetic Compound Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Anti-Breast Cancer Compound Library | Hematonosis Compound Library | Inhibitor Library | Orally Active Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | GPCR Compound Library |
United States
