| Name | UCB-9260 |
| Description | UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer. |
| In vitro | In Hek-293 cells, UCB-9260 (0-10 μM)?inhibits NF-κB with a geometric mean IC50?of 202?nM after TNF (10?pM) stimulation. UCB-9260?inhibits TNF-dependent cytotoxicity with a geometric mean IC50?of 116?nM and a geometric mean IC50?of 120?nM, using human and mouse TNF, respectively. |
| In vivo | UCB-9260 (150?mg/kg; p.o.) treatment twice daily?for 7 days shows a significant reduction of the clinical score. In adult male Balb/c mice, UCB-9260?(10-300?mg/kg; p.o.) dose-dependently inhibits human and mouse TNF-induced neutrophil recruitment to the peritoneal compartment. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 81.7 mg/mL (192.91 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (11.81 mM), Sonication is recommended.
|
| Keywords | UCB-9260 | UCB9260 | UCB 9260 | Tumor Necrosis Factor Receptor | trimer | TNFR | TNF Receptor | TNF | selective | rheumatoid | neutrophil | Inhibitor | inhibit | cytotoxicity | cytokine | autoimmune | asymmetric | arthritis |
| Inhibitors Related | Kaolin | Undecane | Fluorene | Acetylcysteine | Ethyl palmitate | Gum arabic | 1,8-Cineole | Dodecane | 1,4-Naphthoquinone | Tributyrin | Glucosamine | Apremilast |
| Related Compound Libraries | Apoptosis Compound Library | NF-κB Signaling Compound Library | Bioactive Compound Library | Anti-Alzheimer's Disease Compound Library | Cytokine Inhibitor Library | Membrane Protein-targeted Compound Library | HIF-1 Signaling Pathway Compound Library | Inhibitor Library | NO PAINS Compound Library | Orally Active Compound Library | Immuno-Oncology Compound Library | Bioactive Compounds Library Max |