| Name | Urolithin A |
| Description | Urolithin A is a natural product, a metabolite of ellagic acid, which inhibits DNA synthesis and induces apoptosis and autophagy. Urolithin A exhibits antioxidant, anti-inflammatory and antitumor activities. |
| In vitro | METHODS: Human colorectal cancer cells SW620 were treated with Urolithin A (0-30 µM) for 24 h. Cell viability was measured by MTT assay.
RESULTS: A dose-dependent decrease in proliferation was observed in Urolithin A-treated cells. [1]
METHODS: Human colorectal cancer cells HT29, SW480 and SW620 were treated with Urolithin A (20-100 µM) for 48 h, and the expression levels of target proteins were detected by Western Blot.
RESULTS: Treatment of CRC cells with different concentrations of Urolithin A resulted in a significant increase in Cyclin B1 and CDK6, suggesting a strong cell cycle accumulation in G2/M phase. [2] |
| In vivo | METHODS: To investigate the effects on Alzheimer's disease (AD), Urolithin A (300 mg/kg, 0.5% carboxymethylcellulose) was administered orally once daily for 14 days to APP/PS1 mouse models.
RESULTS: Urolithin A ameliorated cognitive deficits, prevented neuronal apoptosis, and enhanced neurogenesis in APP/PS1 mice.Urolithin A attenuated Aβ deposition and periplaque microglia and astrocyte hyperplasia in the cortex and hippocampus. Urolithin A affects key cell signaling pathways, particularly by enhancing brain AMPK activation, decreasing activation of P65NF-κB and P38MAPK, and inhibiting degradation of Bace1 and APP. [3] |
| Storage | Keep away from direct sunlight | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 242.5 mg/mL (1062.66 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (21.91 mM), Solution.
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| Keywords | Urolithin A | Reactive Oxygen Species | Inhibitor | inhibit | Endogenous Metabolite | Drug Metabolite | DNA/RNA Synthesis | DNA synthesis | Autophagy | apoptosis |
| Inhibitors Related | Sucrose | Aceglutamide | Hemin | Nicotinamide riboside malate | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Ethyl linoleate | Glycerol | Thymidine | Corn starch | Gluconate Calcium |
| Related Compound Libraries | Polyphenolic Natural Product Library | Bioactive Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Natural Product Library | Microbial Natural Product Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Gut Microbial Metabolite Library | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
United States
