| Name | Urolithin C |
| Description | Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway. |
| In vitro | Urolithin C is a glucose-dependent activator of insulin secretion acting by facilitating L-type Ca2+ channel opening and Ca2+ influx into pancreatic β-cells.Urolithin C enhanced glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation as shown by higher phosphorylation levels in INS-1 β-cells[2]. Urolithin C stimulates reactive oxygen species (ROS) formation[2]. |
| In vivo | In male Wistar rat, the half-life of the terminal part is 11.3 h and the total clearance (CL/F) is 3.41 L/h/kg. The initial volume of distribution (V1/F) is 0.831 L/kg and the steady-state volume of distribution (Vss/F) is 55.6 L/kg after the intraperitoneal administration of Urolithin C (10 mg/kg)[3]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 64.67 mg/mL (264.82 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (8.19 mM), Sonication is recommended.
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| Keywords | β-cells | Urolithin C | ROS | ReactiveOxygenSpecies | Reactive Oxygen Species | Polyphenols | mitochondria | metabolite | Insulin Receptor | insulin | Inhibitor | inhibit | IGF1R | gut-microbial | glucose-dependent | ERK1/2 | EndogenousMetabolite | Endogenous Metabolite | CalciumChannel | Calcium Channel | Ca2+ channels | Ca channels | Apoptosis | anti-diabetic |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | 2,4,6-Tri-tert-butylphenol | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Ethyl linoleate | Malic acid | Glycerol | Thymidine | Gluconate Calcium |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Pain-Related Compound Library | Bioactive Compound Library | Tyrosine Kinase Inhibitor Library | Kinase Inhibitor Library | Natural Product Library | Microbial Natural Product Library | Natural Product Library for HTS | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Gut Microbial Metabolite Library | Ion Channel Targeted Library |
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