| Name | Valecobulin hydrochloride |
| Description | Valecobulin hydrochloride (CKD-516 hydrochloride) is the valine prodrug and vasoblocker of S516. Valecobulin hydrochloride (CKD-516 hydrochloride) has a potent inhibitory effect on β-tubulin polymerization and has significant anti-tumor activity against solid tumors in mice and humans. |
| In vivo | METHODS: Nude mice carrying human colonic HCT116 and human colonic overexpression of the P-gp transporter HCT15 were treated with Valecobulin hydrochloride (CKD-516 hydrochloride) (5 mg/kg and 10 mg/kg, intraperitoneal injection, Q4D 4).
RESULTS The IR of Valecobulin hydrochloride (CKD-516 hydrochloride) in HCT116 nude mice was 36% and 65%, respectively, and tumor growth was significantly inhibited in a dose-dependent manner; Valecobulin hydrochloride (CKD-516 hydrochloride) also showed resistance to MDR The potent antitumor activity of positive cell lines (HCT15), with IRs of 12% and 5%, respectively. [2] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 145 mg/mL (253.03 mM), Sonication is recommended.
H2O : 50 mg/mL (87.25 mM), Sonication is recommended.
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| Keywords | β-tubulin polymerization | β-tubulin | VDA | Valecobulin hydrochloride | Valecobulin | S516 | prodrug | MicrotubuleAssociated | Microtubule/Tubulin | Microtubule Associated | Inhibitor | inhibit | CKD-516 Hydrochloride | CKD516 Hydrochloride | CKD-516 | CKD516 | CKD 516 Hydrochloride | CKD 516 | antitumor |
| Inhibitors Related | Flubendazole | N-Phenylbenzylamine | Mebendazole | 4-Isopropoxybenzoic acid | Pregnenolone acetate | Oxfendazole | α-Cyclodextrin | Methylene Blue trihydrate | Paclitaxel | 4'-Demethylepipodophyllotoxin | Albendazole | Colchicine |
| Related Compound Libraries | Bioactive Compound Library | Anti-Cancer Clinical Compound Library | Microtubule-Targeted Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Clinical Compound Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library | High-Efficiency Gene Editing Small Molecule Library |
United States
