Valganciclovir hydrochloride NEW

Manufacturer Provide High Quality Valganciclovir Hydrochloride CAS 175865-59-5 Valganciclovir HCl

Introduction

Product Name: Valganciclovir hydrochloride

Other Name :L-Valine,2-[(2-aMino-1,6-dihydro-6-oxo-9H-purin-9-yl)Methoxy]-3-hydroxypropylester,hydrochloride(1:1);2-[(2-amChemicalbookino-6-oxo-6,9-dihydro-3H-purin-9-yl)methoxy]-3-hydroxypropyl(2S)-2-amino-3-methylbutanoatehydrochloridehydrate;

CAS NO:175865-59-5

Purity: 99%min
Appearance:White crystalline powder

Molecular formula: C14H23ClN6O5

MW:390.82

Melting Point :162-164°C

Storage :Keep in dark place,Inert atmosphere,Room temperature

Valganciclovir is a DNA polymerase inhibitor. After oral administration, ganciclovir is rapidly hydrolyzed into ganciclovir under the action of intestinal mucosal cell esterase and liver esterase, so its pharmacodynamic characteristics are the pharmacodynamic characteristics of ganciclovir. Ganciclovir can produce ganciclovir triphosphate by enzymatic phosphorylation in virus and cell, which competes with deoxyguanosine triphosphate (dGTP) as the substrate of viral DNA polymerase, thus inhibiting the synthesis of viral DNA and producing anti-CMV activity.
 

Is used for preventing and treating CMV infection secondary to organ transplant recipients. This drug is a prodrug of ganciclovir, and it is an active valine ester of ganciclovir. After oral administration, it can be rapidly hydrolyzed into ganciclovir by phosphatase in intestinal and liver cells. Its antiviral spectrum and action mechanism are similar to ganciclovir, but its bioavailability is significantly higher than that of ganciclovir. Its oral absorption bioavailability is 62.4%, which is 10 times that of ganciclovir, while its toxicity is greatly reduced..