| Name | Vecuronium bromide |
| Description | Vecuronium bromide (ORG NC 45) is a synthetic, intermediate-acting, mono-quaternary steroid that functions as a non-depolarizing neuromuscular blocking agent with muscle relaxant properties. |
| In vitro | Vecuronium inhibits both forms of the muscle-type acetylcholine receptor (IC50: 1-2 nM). Vecuronium combined with methylprednisolone shows additive effects on both receptor forms.[1] Vecuronium interferes with nicotinic processes in the carotid body and inhibits the chemoreceptor neural response to hypoxia. Vecuronium significantly attenuates the increase in CSNA (DeltaCSNA) in response to hypoxia in the carotid body.[2] |
| In vivo | Vecuronium has a higher biliary clearance than pancuronium in the rats.[3] |
| Storage | 02 | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (5.17 mM), Sonication is recommended.
H2O : 4 mg/mL (6.27 mM), Sonication is recommended.
Ethanol : 93 mg/mL (145.83 mM), Sonication is recommended.
DMSO : 100 mg/mL (156.81 mM), Sonication is recommended.
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| Keywords | Vecuronium Bromide | Vecuronium | ORG NC-45 | ORG NC45 | Nicotinic acetylcholine receptors | neurological disease | nAChR inhibitor | nAChR | muscle relaxant | Inhibitor | inhibit | cancer |
| Inhibitors Related | Adiphenine hydrochloride | Levamisole hydrochloride | Ethyl (triphenylphosphoranylidene) acetate | Urethane | Hexamethonium Bromide | Ribavirin | Adenine | Mitotane | Choline chloride | Propoxur | N,N-Dicyclohexylcarbodiimide | Arecoline |
| Related Compound Libraries | Pain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Anti-Parkinson's Disease Compound Library | Drug Repurposing Compound Library | Inhibitor Library | FDA-Approved Drug Library | Bioactive Compounds Library Max | Bioactive Lipid Compound Library | Ion Channel Targeted Library |
United States
