| Name | Vedaprofen |
| Description | Vedaprofen (PM 150) inhibits COX-1 and reduces prostaglandin H2 synthesis with anti-inflammatory activities. Vedaprofen is an inhibitor of Escherichia coli sliding clamp with the IC50 of 222 μM and Ki of 131 μM. |
| In vitro | Vedaprofen blocks the activity of the E. coli DNA polymerase III β subunit, preventing DNA replication and repair[1]. Vedaprofen inhibits horse serum TxB2 and horse exudate PGE2 with IC50s of 9 ng/mL and 630 ng/mL, respectively[3]. |
| In vivo | In beagle dogs, the absorption of Vedaprofen (0.5 mg/kg; oral) was rapid (tmax 0.63 h) and almost complete (bioavailability 86%). The terminal half-lives after intravenous and oral administration, 16.8 and 12.7 h respectively, were of the same order of magnitude. Vedaprofen does not accumulate in plasma[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 10 mg/mL (35.41 mM), Sonication is recommended.
DMF : 25 mg/mL (88.53 mM), Sonication is recommended.
DMSO : 50 mg/mL (177.07 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (7.08 mM), Sonication is recommended.
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| Keywords | Vedaprofen | sliding clamp | serum TxB2 | ProstaglandinReceptor | Prostaglandin Receptor | PM-150 | PM150 | PGE2 | NSAID | nonsteroidal | Inhibitor | inhibit | exudate PGE2 | Escherichia coli | E. coli | Cyclooxygenase | COX-1 selective | COX-1 | COX | CERM-10202 | CERM10202 | Bacterial | anti-inflammatory drug |
| Inhibitors Related | Neomycin sulfate | Levulinic acid | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Doxycycline | Hyaluronic acid sodium (MW 20 kDa) | Trometamol | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate | BES |
| Related Compound Libraries | Nonsteroidal Anti-Inflammatory Compound Library | Pain-Related Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Compound Library | Anti-Infection Compound Library |
United States
