| Name | Verapamil hydrochloride |
| Description | Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent. |
| Cell Research | Verapamil is dissolved in DMSO and stored, and then diluted with appropriate media before use[1]. Cells (1×105) are treated with 10 nM Bortezomib and/or 70 μM Verapamil for 16 hours and incubated for another 4 hours with Alamar-Blue. Activity of the mitochondrial dehydrogenase results in conversion of the coloring, which is followed by measurement of the absorption using a spectrophotometer[1]. |
| In vitro | Verapamil exhibits antiarrhythmic properties, reduces myocardial oxygen consumption in rats, and preserves Cx43 protein. |
| In vivo | Verapamil and Diltiazem essentially inhibit the hydrolase activity of recombinant CES2, with inhibition constants (Ki) of 0.25 ± 0.02 μM and 3.84 ± 0.99 μM, respectively. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.07 mM), Sonication is recommended.
DMSO : 86.67 mg/mL (176.5 mM), Sonication is recommended.
H2O : 24.6 mg/mL (50.1 mM), Sonication is recommended.
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| Keywords | Verapamil hydrochloride | Verapamil hydrochlorid | Verapamil | pressure | P-gp (P-glycoprotein) | P-gp | Pgp | P-glycoprotein | Palbociclib | Multidrug resistance protein 1 | MDR1 | lysosomotropic | Inhibitor | inhibit | high | Cytochrome P450 | CYPs | CYP3A4 | Cluster of differentiation 243 | CD243 | CalciumChannel | Calcium Channel | Calcan Hydrochloride | Ca2+ channels | Ca channels | blood | antiarrhythmic | angina | ABCB1 | (±)-Verapamil |
| Inhibitors Related | Quadrol | 2,4,6-Tri-tert-butylphenol | Chlorocresol | L-Ascorbic acid | Ipriflavone | Benzyl alcohol | Naringin | L-Ascorbic acid sodium salt | 2-Nitrobenzoic acid | Magnesium Chloride Hexahydrate | Dibenzothiophene | Magnesium sulfate |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Pain-Related Compound Library | Anti-Cancer Clinical Compound Library | Anti-Viral Compound Library | Drug Repurposing Compound Library | Inhibitor Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library |
United States
