| Name | Vesnarinone HCl |
| Description | Vesnarinone HCl (OPC-8212 HCl) is an orally active phosphodiesterase 3 (PDE3) inhibitor.Vesnarinone HCl modulates calcium and potassium ions, increasing calcium flux and decreasing potassium flux.Vesnarinone HCl is a new positive inotropic compound that enhances myocardial contractility and can be be used in heart failure studies. |
| In vitro | Vesnarine (60 and 100 μg/mL; 48 h) in a dose-dependent manner to inhibit cell growth.[3]
Vesnarine (60 μg/mL; 48 h) induces G1 phase arrest and cell apoptosis.[3]
Vesnarine (60 μg/mL; 0, 12, 24, and 48 h) increased the expression of p21 mRNA and slightly decreased the p21 protein.[3] |
| In vivo | Vesnarinone (3-300 μM) increases contractile tension in isolated ventricular muscles of dogs, cats, rabbits, and guinea pig in a dose-dependent manner.[5]
Vesnarinone (Oral and i.v.) administration of vesnarinone increases right ventricular pressure with no effect on heart rate in dog models of tricuspid insufficiency- and pulmonary stenosis-induced congestive heart failure. It also increases contractility and coronary flow while decreasing heart rate in a guinea pig model of aortic stenosis-induced congestive heart failure. Formulations containing vesnarinone have been used for the treatment of congestive heart failure.[6] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Vesnarinone HCl | PotassiumChannel | Potassium Channel | PDE3 | CalciumChannel | Calcium Channel | Ca(2+) receptor |
| Inhibitors Related | Quadrol | 2,4,6-Tri-tert-butylphenol | Balipodect | Chlorocresol | L-Ascorbic acid | D(+)-Raffinose pentahydrate | 1,8-Cineole | Indomethacin | L-Ascorbic acid sodium salt | Magnesium Chloride Hexahydrate | Sildenafil citrate | Magnesium sulfate |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Calcium Channel Compound Library | Anti-Viral Compound Library | Drug Repurposing Compound Library | Neuroprotective Compound Library | Inhibitor Library | Clinical Compound Library | Bioactive Compounds Library Max | Potassium Channel Targeted Library | Ion Channel Targeted Library |
United States
