| Name | VGX-1027 |
| Description | VGX-1027 (GIT 27) is an isoxazole compound with various immunomodulatory properties. |
| In vitro | VGX-1027 enhances survival rates and ameliorates clinical and histopathological signs in the NZB/NZW F1 model of systemic lupus erythematosus, thereby improving disease progression. It prevents the spontaneous development of Type 1 diabetes in NOD mice and counters the acceleration of diabetes induced either by cyclophosphamide assault or by the adoptive transfer of diabetogenic spleen cells in NOD mice. Furthermore, VGX-1027 reduces clinical symptoms of diabetes induced by MLD-STZ and inhibits pathological histological changes in the pancreas. |
| In vivo | VGX-1027 exhibits inhibitory effects on the proliferation of gut bacterial antigen-reactive CD4+ CD25- T cells in vitro. It significantly suppresses the accumulation of TNF-α and nitrites induced by IL-1β/IFN-γ, and notably enhances cell survival by interfering with the toxic effects of cytokines. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 20.5 mg/mL (99.9 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (9.75 mM), Sonication is recommended.
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| Keywords | VGX-1027 | Tumor Necrosis Factor Receptor | TNF-α | TNFR | TNF Receptor | Interleukin Related | Interleukin | Inhibitor | inhibit | ILReceptor | IL-1β | IL-10 | IL Receptor | GIT-27 | GIT27 |
| Inhibitors Related | Kaolin | Acetylcysteine | Rhamnose monohydrate | Gum arabic | D(+)-Raffinose pentahydrate | Hydroxypropyl Cellulose | 1,8-Cineole | 1,4-Naphthoquinone | Tributyrin | Glucosamine | Gluconate Calcium | Magnesium sulfate |
| Related Compound Libraries | Nonsteroidal Anti-Inflammatory Compound Library | NF-κB Signaling Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Diabetic Compound Library | Drug Repurposing Compound Library | Angiogenesis related Compound Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Metabolism Disease Compound Library |
United States
