| Name | Vicenin 2 |
| Description | Vicenin 2 is an angiotensin-converting enzyme (ACE) inhibitor (IC50=43.83 μM) from the aerial parts of Desmodium styracifolium. Vicenin 2 is an inhibitor of α-glucosidase, PTP1B, and RLAR. Vicenin 2 has hepatoprotective, anti-cancer, antioxidant and anti-inflammatory activities, and DTL co-administration is more effective than either of the single agents in androgen-independent prostate cancer. Vicenin 2 might be a useful lead for the development of multiple target-oriented therapeutic modalities for the treatment of diabetes and diabetes-associated complications. Vicenin 2 could act as a UV light barrier to protect the plants. |
| In vitro | Lychnophora salicifolia, commonly known as 'arnicão', is used as an anti-inflammatory agent and as a flavoring agent in the Brazilian traditional spirit 'cachaça'.METHODS AND RESULTS: In this work, the permeation process of Vicenin -2 (1) and lychnopholic acid (2) (major secondary metabolites from the hydroalcoholic extract) was investigated using Caco-2 cells. For this investigation, a new HPLC-DAD method was developed and validated for the quantification step. It was observed that 2 crosses the Caco-2 cell monolayer by passive diffusion. On the other hand, 1 was not transported, suggesting no absorption and no efflux of this compound in Caco-2 cells. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (3.36 mM), Sonication is recommended.
DMSO : 150 mg/mL (252.3 mM), Sonication is recommended.
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| Keywords | Vicenin-2 | Vicenin2 | Vicenin 2 | p53 | mTOR | Inhibitor | inhibit | EGFR | c-Myc | Angiotensin-converting Enzyme (ACE) | Akt | ACE |
| Inhibitors Related | H-ASP-PHE-OH | Losartan potassium | Tranilast | Telmisartan | Lisinopril dihydrate | Sacubitril/Valsartan | Ursodeoxycholic acid | Benzyl benzoate | Irbesartan | Losartan | Diisononyl phthalate | Captopril |
| Related Compound Libraries | Marine Natural Product Library | Polyphenolic Natural Product Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Miao medicine Compound Library | Saccharide and Glycoside Natural Product Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Anti-Cancer Active Compound Library |
United States
