| Name | Vidarabine |
| Description | Vidarabine (Adenine Arabinoside) is a nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the VACCINIA VIRUS and varicella zoster virus. |
| In vitro | Vidarabine and Acyclovir have a synergistic effect on wild type . Vidarabine is capable of inhibiting acyclovir-resistant/TK-deficient mutants of HSV and VZV, because it is phosphorylated to its active vidarabine–triphosphate form by cellular kinases and is not dependent for its activation on the viral TK. [1] Vidarabine and acyclovir (ACV) alone show a concentration-dependent inhibition of plaque formation of HSV-1 in Vero cells. Vidarabine combined with acidic protein bound polysaccharide (APBP) show synergistic effects on the plaque formation of HSV-1 in Vero cells. [2] Vidarabine acts directly on the DNA polymerase of varicella-zoster virus (VZV) and double-strand DNA viruses, including human adenoviruses. Vidarabine specifically inhibits adenovirus type 11 replication without obvious cytotoxicity in vitro. Vidarabine acts less on the synthesis of early proteins but rather on those after DNA replication. [3] Vidarabine is an antiviral drug with activity against herpes viruses, poxviruses, and certain rhabdoviruses, hepadnarviruses, and RNA tumor viruses. Vidarabine also is active against vaccinia virus both in vitro and in vivo. [4] |
| In vivo | Vidarabine is rapidly deaminated to 9-β-D-arabinofuranosyl hypoxanthine (Ara-Hx) as the principal metabolite. [3] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (7.48 mM), Sonication is recommended.
H2O : 3 mg/mL (11.23 mM), Sonication is recommended.
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 125 mg/mL (467.74 mM), Sonication is recommended.
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| Keywords | Vidarabine | TyrosineKinases | Tyrosine Kinases | RNASynthesis | RNA Synthesis | Orthopoxvirus | NucleosideAntimetabolite | Nucleoside Antimetabolite/Analog | Nucleoside Antimetabolite | Inhibitor | inhibit | HSV | Herpes simplex virus | DNASynthesis | DNA Synthesis | DNA polymerase | Antibiotic | Analog | 9-beta-D-Arabinofuranosyladenine | 9-b-D-Arabinofuranosyladenine |
| Inhibitors Related | Neomycin sulfate | Stavudine | Ampicillin sodium | Kanamycin sulfate | Guanidine hydrochloride | Sulfamethoxazole sodium | Terbinafine hydrochloride | Metronidazole | Avermectin B1a | Doxycycline | Penicillin G sodium salt | Thymidine |
| Related Compound Libraries | Bioactive Compound Library | Tyrosine Kinase Inhibitor Library | Drug Repurposing Compound Library | Natural Product Library | Anti-Viral Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Microbial Natural Product Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Anti-infective Natural Product Library | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
United States
