| Name | Vinblastine |
| Description | Vinblastine inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM, used to treat certain kinds of cancer. |
| Cell Research | Six-well treatment plates are set up that contained 5 × 104 cells/mL in each well, suspended in 3 mL culture medium, and these are treated with vinblastine for 3 h followed by 21 h growth. (Only for Reference) |
| In vitro | Vinblastine does not depolymerize spindle microtubules, yet it powerfully blocks mitosis (for example, IC50 0.8 nM in HeLa cells) and cells die by apoptosis[2]. In NB4 cells, vinblastine produces alteration of p53 and DNA fragmentation. Vinblastine treatment has an antiproliferative effect via the induction of apoptosis producing Bax/Bcl-2 imbalance. Vinblastine treatment suppresses NFκB expression and depresses NFκB-DNA binding activity while maintaining JNK activation that subsequently results in apoptotic response through caspase-dependent pathway[3]. Vinblastine is found to trigger apoptosis as evidenced by the loss of mitochondrial membrane potential, the release of both cytochrome c and apoptosis inducing factor, activation of caspase-9 and 3, and cleavage of Poly (ADP-ribose)-Polymerase[4]. |
| In vivo | Vinblastine is a widely used anticancer drug with undesired side effects. Its conjugation with carrier molecules could be an efficient strategy to reduce these side effects[5]. |
| Storage | Store at low temperature | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 6 mg/mL (7.4 mM), Sonication is recommended.
DMSO : 250 mg/mL (308.27 mM), Sonication is recommended.
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| Keywords | Vinblastine | nAChR | MicrotubuleAssociated | Microtubule Associated |
| Inhibitors Related | Adiphenine hydrochloride | Levamisole hydrochloride | Flubendazole | Urethane | Ribavirin | Adenine | α-Cyclodextrin | Mitotane | Methylene Blue trihydrate | Choline chloride | N,N-Dicyclohexylcarbodiimide | Arecoline |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Protease Inhibitor Library | Drug Repurposing Compound Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | Ion Channel Targeted Library | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
United States
