Vitamin D3

$ 20.00 /1KG

Min. Order1KG
Purity99%
Cas No67-97-0
Supply AbilityEx 20 tons
Update time2022-09-15

Hebei Anda Technology Co., LTD

VIP4Y

China

Chemical Properties

Product Name	Vitamin D3
CAS No	67-97-0
EC-No	200-673-2
Min. Order	1KG
Purity	99%
Supply Ability	Ex 20 tons
Release date	2022/09/15

Use of Vitamin D3

Cholecalciferol(Vitamin D3) is a naturally occuring form of vitamin D; Reported that upon metabolic activation, Cholecalciferol induces cell differentiation and prevents proliferation of cancer cells. IC50 value:Target: Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.

Description	Cholecalciferol(Vitamin D3) is a naturally occuring form of vitamin D; Reported that upon metabolic activation, Cholecalciferol induces cell differentiation and prevents proliferation of cancer cells. IC50 value:Target: Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.
Related Catalog	Signaling Pathways >> Vitamin D Related >> VD/VDR Research Areas >> Cancer Natural Products >> Others
Target	Human Endogenous Metabolite
Solvent	In Vitro: DMSO : 10 mg/mL (26.00 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble) In Vivo: 1.Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% saline Solubility: ≥ 1 mg/mL (2.60 mM); Clear solution 2.Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in saline) Solubility: 1 mg/mL (2.60 mM); Suspended solution; Need ultrasonic 3.Add each solvent one by one: 10% DMSO 90% corn oil Solubility: ≥ 1 mg/mL (2.60 mM); Clear solution
Solubility	1 mM2.5998 mL12.9992 mL25.9983 mL5 mM0.5200 mL2.5998 mL5.1997 mL10 mM0.2600 mL1.2999 mL2.5998 mL
Storage	4°C, protect from light, stored under nitrogen
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)C)([H])/C(CCC1)=C/C=C3C(CC[C@H](O)C\3)=C
References	[1]. Leibowitz SB, Kantoff PW. Differentiating agents and the treatment of prostate cancer: Vitamin D3 and peroxisome proliferator-activated receptor gamma ligands. Semin Oncol. 2003 Oct;30(5):698-708. [2]. Di Rosa M, Malaguarnera M, Nicoletti F, Malaguarnera L. Vitamin D3: a helpful immuno-modulator. Immunology. 2011 Oct;134(2):123-39. doi: 10.1111/j.1365-2567.2011.03482.x. [3]. Krishnan AV, Feldman D. Mechanisms of the anti-cancer and anti-inflammatory actions of vitamin D. Annu Rev Pharmacol Toxicol. 2011;51:311-36. doi: 10.1146/annurev-pharmtox-010510-100611. [4]. Nigwekar SU, Bhan I, Thadhani R. Ergocalciferol and cholecalciferol in CKD. Am J Kidney Dis. 2012 Jul;60(1):139-56. doi: 10.1053/j.ajkd.2011.12.035.
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