| Name | VK-28 |
| Description | VK-28 is a brain permeable iron chelator with neuroprotection. VK-28 inhibits basal as well as iron-induced mitochondrial lipid peroxidation. |
| In vitro | VK-28 inhibited both basal and Fe/ascorbate induced mitochondrial membrane lipid peroxidation, with an IC50 of 12.7 microM comparable to that of the prototype iron chelator, desferal, which does not cross the blood brain barrier[1]. |
| In vivo | VK-28(1 microg; i.c.v.) was able to completely protect against ICV 6-OHDA (250 microg) induced striatal dopaminergic lesion, as measured by dopamine (DA), dihydroxyphenylacetic acid (DOPAC) and homovanilic acid (HVA) levels. VK-28 (1 and 5 mg/kg; i.p.) daily for 10 and 7 days, respectively, demonstrated significant neuroprotection against ICV 6-OHDA at the higher dose, with 68% protection against loss of dopamine at 5mg/kg dosage of VK-28[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 45 mg/mL (156.6 mM), Sonication is recommended.
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| Keywords | VK-28 | VK28 | VK 28 | MitochondrialMetabolism | Mitochondrial Metabolism | Mitochondria | Lipid | iron chelator |
| Inhibitors Related | Hemin | Acetylcysteine | L-Glutamic acid | Sorafenib | Curcumin | L-Cystine | L-Glutamine | (-)-Epigallocatechin Gallate | Coenzyme Q10 | Baicalein | Sodium Molybdate | 4-Pentenoic acid |
| Related Compound Libraries | Ferroptosis Compound Library | Cuproptosis Compound Library | Glycometabolism Compound Library | Bioactive Compound Library | Multi-Target Compound Library | Neuroprotective Compound Library | Inhibitor Library | Mitochondria-Targeted Compound Library | Metabolism Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max |