| Name | VUF10460 |
| Description | VUF10460, a non-imidazole histamine H4 receptor agonist, [58C8-51-20-3] is structurally classified under the chlorobenzylpiperazine ethers with the IUPAC designation (2-[(2-chlorophenyl)methyl]-1-piperazinyl)(1H-indol-3-yl)methanone. It is typically utilized in pharmacological research and exhibits specificity for the H4 subtype, making it a valuable tool in immunological studies. |
| In vitro | UF10460 exhibits binding affinities to rat H3 and H4 receptors with pKi values of 5.75 and 7.46, respectively, whereas VUF10460 demonstrates approximately 50-fold selectivity for the rat H4 receptor over the H3 receptor [1]. |
| In vivo | HCl-induced rat gastric lesions are significantly enhanced by the H4 receptor agonist VUF10460, an effect not altered by the H4 receptor antagonist JNJ7777120[1]. VUF10460 exhibits approximately 50-fold selectivity for the rat H(4) receptor over the H(3) receptor. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (7.43 mM), Sonication is recommended.
DMSO : 45 mg/mL (167.08 mM), Sonication is recommended.
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| Keywords | VUF-10460 | VUF10460 | VUF 10460 | Inhibitor | inhibit | HistamineReceptor | Histamine Receptor | H4 receptor |
| Inhibitors Related | Undecane | Betahistine mesylate | Histamine dihydrochloride | Meclizine dihydrochloride | Lidocaine | Famotidine | Sodium butanoate | Nizatidine | Alginic acid | Mianserin hydrochloride | Trazodone hydrochloride | Doxepin hydrochloride |
| Related Compound Libraries | Histamine & Melatonin Receptor-Targeted Compound Library | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Anti-Obesity Compound Library | Anti-Parkinson's Disease Compound Library | NO PAINS Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | GPCR Compound Library |
United States
