| Name | WAY-100635 |
| Description | WAY-100635 is a potent 5-HT 1A receptor antagonist with an IC50 = 0.91 nM that abrogates the reduction in hippocampal CA1 pyramidal neuron firing frequency during conditioned reflexes; it also acts as a dopamine D4 receptor agonist with an affinity of 3.3 nM. |
| In vitro | The functional properties and binding affinities of WAY-100635 are evaluated in HEK 293 cells stably expressing dopamine D 2L or D 4.4 receptors [1]. WAY-100635 has binding affinities of 940, 370, and 16 nM on D 2L, D 3, and D 4.2 receptors, respectively. Saturation analyses shows that the K d of [ 3 H] WAY-100635 at D 4.2 receptors is 2.4 nM. WAY-100635 is potent agonist in HEK-D 4.4 cells with EC 50 of 9.7 nM. WAY-100635 possesses high affinity for D 4.4 receptor (3.3 nM) [1]. |
| In vivo | Treatment with WAY-100635 (1 mg/kg; subcutaneous injection; male Sprague-Dawley rats) abolishes the reduction of the severity of abstinence signs induced by Rhodiola rosea administration in nicotine-dependent rat [2]. Animal Model: Male Sprague-Dawley rats (220-240 g) [2] Dosage: 1 mg/kg Administration: Subcutaneous injection (Pharmacokinetic study) Result: Reduced total abstinence score, increased immobility time and the burying behavior was increased. |
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.73 mM), Sonication is recommended.
DMSO : 50 mg/mL (118.33 mM), Sonication is recommended.
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| Keywords | WAY-100635 | WAY 100635 |
| Inhibitors Related | Alverine citrate | Dapoxetine hydrochloride | Cefaclor monohydrate | Hexamethonium Bromide | Octopamine hydrochloride | 1,8-Cineole | L-DOPA | Creatine | Oxolinic acid | Mianserin hydrochloride | Trazodone hydrochloride | Cinchonidine |
| Related Compound Libraries | Bioactive Compound Library | Neuronal Signaling Compound Library | ReFRAME Related Library | Bioactive Compounds Library Max | GPCR Compound Library | Serotonin Receptor-Targeted Compound Library |
United States
