Xanomeline Sulfone
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E-mail: anna@molcoo.com
Product Code：X002022
English Name：Xanomeline Sulfone
English Alias：3-(hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole 1,1-dioxide
CAS No.：Not provided
Molecular Formula：C₁₄H₂₃N₃O₃S
Molecular Weight：313.42
High-Purity Reference Standard：Confirmed by HPLC (≥99.0%), NMR (1H, 13C), HRMS, and elemental analysis, providing an accurate standard for Xanomeline-related impurity analysis.
Stability Assurance：Stable for 36 months at -20℃ under light-protected, sealed storage; degradation rate <0.3% in methanol-water mixture within 6 months.
Quality Control Testing：Used for UPLC-MS/MS detection of sulfone impurities in Xanomeline API and formulations, controlling content to meet ICH Q3A standards (single impurity limit ≤0.1%).
Process Optimization Research：Monitors the formation pathway of this sulfone impurity during Xanomeline synthesis or storage. Optimizing oxidation conditions (e.g., avoiding strong oxidants, controlling temperature ≤20℃) reduces impurity generation by >40%.
Method Validation：Serves as a standard for developing sulfone impurity detection methods, verifying UPLC resolution (≥3.0) and LOD (0.01 ng/mL).
Xanomeline, a selective muscarinic M1 receptor agonist, treats Alzheimer's disease by enhancing cholinergic function. Xanomeline Sulfone, an oxidative degradation impurity, may originate from excessive oxidation of the thiadiazole ring sulfur (e.g., exposure to strong oxidants or long-term light during storage). Its sulfone group (-SO₂-), tetrahydropyridine ring, and hexyloxy group may affect drug hydrophilicity, metabolic pathways, and blood-brain barrier permeability. Strict impurity control is critical for CNS drugs, making research on this impurity essential for drug quality.
NOTE！
We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!
WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com
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