| Name | Xylitol |
| Description | Xylitol (Ribitol) is a five-carbon sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener. |
| Cell Research | In vitro tube formation assay:HUVECs (2×104 cells) are seeded on a layer of previously polymerized Matrigel and treated with or without xylitol. Matrigel culture is incubated at 37°C. After 6 h, changes in cell morphology are captured through a phase contrast microscope and photographed at ×40 magnification. Each sample is assayed in duplicate and independent experiments are repeated three times. (Only for Reference) |
| In vitro | Xylitol is reported to have an inhibitory effect on LPS-induced inflammatory cytokine expression[2]. Xylitol strongly inhibits tube formation, migration, and invasion of HUVECs. Xylitol decreases the mRNA expression of key angiogenic molecules and their receptors (VEGF, KDR, bFGF and bFGFR-II) in a dose-dependent manner. Also, it suppresses NF-κB and Akt activation of HUVECs[1]. |
| In vivo | Xylitol triggers the release of insulin in dogs[3] and inhibits in vivo angiogenesis. It prominently inhibits the formation of neo-microvessels in the Matrigel assay, and reduces the hemoglobin content in the Matrigel plug[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 197.2 mM, Sonication is recommended.
DMSO : 45 mg/mL (295.76 mM), Sonication is recommended.
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| Keywords | Xylitol | Inhibitor | inhibit | EndogenousMetabolite | Endogenous Metabolite | Autophagy | 16277-71-7 |
| Inhibitors Related | Sucrose | Hydroxychloroquine | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | Formamide | Paeonol | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Anti-Cancer Clinical Compound Library | Saccharide and Glycoside Natural Product Library | Natural Product Library | Anti-Cancer Approved Drug Library | Natural Product Library for HTS | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
United States
