| Name | Xyloidone |
| Description | Xyloidone (NSC-106453) exhibits antifungal activity and completely inhibits the mycelial growth of B. cinerea, Colletotrichum acutatum Simmonds, Colletotrichum gloeosporioides Simmonds, M. grisea, and Pythium ultimum Trow over a range of 0.4-33.3 mg/L. |
| In vitro | Xyloidone controlls the development of rice blast, tomato late blight, wheat leaf rust, barley powdery mildew and red pepper anthracnose (Colletotrichum coccodes (Wallr) S Hughes). Xyloidone is particularly effective in suppressing red pepper anthracnose by 95% at a concentration of 125 mg/L[1]. |
| In vivo | Xyloidone inhibits vessel regeneration, interferes with vessel anastomosis, and limits plexus formation in zebrafish. Xyloidone induces vascular pruning and growth delay in orthotopic mammary tumors in mice. Xyloidone targets cell adhesion by promoting ubiquitination of the Rho-GTPase Rac1, which is frequently up-regulated in many different cancers[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : Soluble
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| Keywords | Xyloidone | NSC-629748 | NSC629748 | Dehydro-alpha-lapachone | Dehydro-a-lapachone | Antifungal |
| Inhibitors Related | Calcium Propionate | Dehydroacetic acid sodium | Potassium gluconate | D-Gluconic acid (solution) (50% in H2O) | Sulfacetamide sodium | Benzyl propionate | Terbinafine hydrochloride | Sodium formate | Magnesium acetate tetrahydrate | Geraniol | L-Citronellol | Benzimidazole |
| Related Compound Libraries | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Rare Natural Product Library | Selected Plant-Sourced Compound Library | Anti-Fungal Compound Library | Natural Product Library | Natural Product Library for HTS | RO5 Drug-like Natural Product Library | Anti-infective Natural Product Library | Bioactive Compounds Library Max | Anti-Infection Compound Library |