| Name | Y-33075 dihydrochloride |
| Description | Y-33075 dihydrochloride is a selective inhibitor of ROCK with an IC50 of 3.6 nM. |
| In vitro | Y-33075 (Y-39983) is a potent inhibitor of ROCK with an IC50 of 3.6 nM and exhibits greater inhibitory effects on PKC and CaMKII compared to Y-27632. The IC50 values for PKC are 9.0 μM for Y-27632 and 0.42 μM for Y-33075, while for CaMKII, the IC50s are 26 μM and 0.81 μM, respectively. The IC50s for Y-27632 and Y-33075 for PKC are 82 and 117 times higher than for ROCK, respectively, and for CaMKII, they are 236 and 225 times higher than for ROCK, respectively [1]. Y-33075 (Y-39983, 10 μM) promotes neurite extension in retinal ganglion cells (RGCs) compared to untreated cells [2], and at 1 μM, it inhibits the histamine-evoked contraction of rabbit ciliary artery segments in Ca2+-free solutions [3]. |
| In vivo | Y-33075 (≥0.01%) significantly lowers intraocular pressure (IOP) at 2 hours after topical administration in rabbits. Y-33075 (0.05%)-treated eyes show significant reduction of IOP between 2 and 7 hours after topical administration in monkeys[1]. Y-33075 (100 μM) increases the regenerating axons of retinal ganglion cells (RGCs) in the eyes of the rats[2]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 150 mg/mL (424.63 mM), Sonication is recommended.
H2O : 50 mg/mL (141.54 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (11.32 mM), Sonication is recommended.
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| Keywords | Y-33075 Dihydrochloride | Y33075 dihydrochloride | Y-33075 | Y33075 | Y 33075 Dihydrochloride | Y 33075 | ROK | ROCK | Rho-kinase | Rho-associated protein kinase | Rho-associated kinase | PKC | Inhibitor | inhibit | CaMKII |
| Inhibitors Related | Trifluoperazine dihydrochloride | Berbamine | Darovasertib | Ellagic acid | α-Vitamin E | RKI-1447 | Dibucaine | Miltefosine | Fasudil hydrochloride | CaMKP Inhibitor | Y-27632 dihydrochloride | (-)-Limonene |
| Related Compound Libraries | Reprogramming Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Epigenetics Compound Library | Kinase Inhibitor Library | Inhibitor Library | Stem Cell Differentiation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Wnt/Hedgehog/Notch Compound Library | TGF-beta/Smad Compound Library |
United States
