| Name | YM17E |
| Description | YM17E is an inhibitor of ACAT with IC50 of 44 nM in rabbit liver microsomes in vitro. |
| In vitro | YM17E is potent in inhibiting ACAT activity in the intestine with IC50 of 34 nM[1]. |
| In vivo | YM17E inhibits the production of [14C]cholesteryloleate from [14C]oleoyl CoA in a dose-dependent manner in both liver and intestinal microsomes used as enzyme sources[1]. YM17E (3, 5, 10 mg/kg, i.v.) significantly inhibits hepatic ACAT activities in a dose-dependent manner. YM17E (oral; i.v.) produces a significant increase in 125I-LDL clearance in atherogenic diet-fed rats. YM17E (3, 10, 30 mg/kg; p.o.) decreases total cholesterol, cholesteryl ester, and non-HDL cholesterol in a dose-dependent manner. YM17E (oral) decreases total cholesterol and cholesteryl ester levels in the liver significantly in a dose-dependent manner[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 12 mg/mL (18.38 mM), Sonication is recommended.
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| Keywords | YM-17E | YM17E | mono- acylglycerol acyltransferase | Inhibitor | inhibit | Diglyceride acyltransferase | Diacylglycerol acyltransferase | Acyltransferase | acyl-CoA:cholesterol acyltransferase | ACAT in rabbit liver microsomes | ACAT |
| Inhibitors Related | Adiphenine hydrochloride | Levamisole hydrochloride | Ethyl (triphenylphosphoranylidene) acetate | Urethane | Ribavirin | Adenine | Mitotane | Choline chloride | Propoxur | N,N-Dicyclohexylcarbodiimide | Arecoline | Xanomeline tartrate |
| Related Compound Libraries | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Neurotransmitter Receptor Compound Library | Inhibitor Library | Lipid Metabolism Compound Library | Metabolism Compound Library | Bioactive Compounds Library Max |