| Name | (Z)-Leukadherin-1 |
| Description | (Z)-Leukadherin-1 (ADH-503 free base) is an allosteric agonist of CD11b. |
| In vitro | (Z)-Leukadherin-1 (4 μM) treatment reduces the numbers of total tumor-infiltrating CD11b+ cells and subsets of CD11b+ monocytes, eosinophils, granulocytes, and macrophages. (Z)-Leukadherin-1 leads to the repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhances dendritic cell responses[1]. |
| In vivo | (Z)-Leukadherin-1 shows a mean half-life of 4.68 and 3.95 h, a maximum concentration of 1716 and 2594 ng/ml and AUC(0-t) in the plasma of 6950 and 13962 ng·h/ml at 30 and 100 mg/kg dosing, respectively. In KPC mice, (Z)-Leukadherin-1 (30, 60, or 120 mg/kg; gavage) delayes tumor progression and leads to a significantly decreased tumor burden in time-point analysis and improved overall survival[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 4 mg/mL (9.49 mM), Sonication and heating to 60℃ are recommended.
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| Keywords | tumor-infiltrating | tumorassociated | repolarization | orally | macrophages | Leukadherin-1 | Inhibitor | inhibit | immunosuppressive | dendritic | ComplementSystem | Complement System | CD11b | allosteric | ADH-503 | ADH503 | ADH 503 | (Z)Leukadherin1 | (Z) Leukadherin 1 |
| Inhibitors Related | Iptacopan hydrochloride | Tirofiban hydrochloride monohydrate | Iptacopan | ADH-503 | Dexamethasone acetate | Dexamethasone | CLT-28643 | Bestatin hydrochloride | Cyclosporin A | Dextran sulfate sodium salt (MW 5000) | 3-Phenoxybenzaldehyde | 2-hydroxy Flutamide |
| Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max |
United States
