| Name | Zinc pyrithione |
| Description | Zinc pyrithione (OM-1563), an antibacterial and antifungal agent can disrupt membrane transport by blocking the proton pump. |
| In vitro | In exposed mussel tissues, Zinc pyrithione accumulates rapidly, with the rate of accumulation being proportional to both exposure concentration and time. Despite a 7-day LC50 (lethal concentration for 50% of the population) of 8.27 μM in relatively higher concentrations of Zinc pyrithione, this indicates a potential threat to coastal ecosystems and marine life, necessitating further investigation into its sub-lethal biological effects. |
| In vivo | As a specific synthetic potentiator, Zinc pyrithione activates homotypic and heterotypic M channels by inducing a resting potential. It is considered a zinc complex. The Pyrithione ligand (formally a monoanion) chelates with Zn2+ through oxygen and iron-sulfur centers. In the crystalline state, Zinc pyrithione exists as a centrosymmetric dimer, with each zinc atom coordinated to two sulfur and three oxygen centers. However, in solution, the dimers dissociate through the cleavage of zinc-oxygen bonds. Although Zinc pyrithione is a dimer, its activity causing cytoplasmic membrane depolarization may originate from the monomer, with an effective concentration for half-maximum effect (K1/2) of approximately 0.3 mM. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 33 mg/mL (103.87 mM), Sonication and heating are recommended.
10% DMSO+90% Corn Oil : 2 mg/mL (6.3 mM), Sonication is recommended.
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| Keywords | Zinc pyrithione | Protonpump | Proton Pump | OM1563 | OM 1563 | Inhibitor | inhibit | Fungal | Bacterial |
| Inhibitors Related | Neomycin sulfate | Calcium Propionate | Adipic dihydrazide | Levulinic acid | D(+)-Raffinose pentahydrate | Benzyl propionate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Fungal Compound Library | Drug Repurposing Compound Library | NO PAINS Compound Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Cosmetic Ingredient Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Infection Compound Library | Anti-Cancer Drug Library |
United States
