| Name | Zingerone |
| Description | Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antidiarrhoeic, antilipolytic, antispasmodic, and anti-tumor properties. Zingerone (Gingerone) alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways, acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells. |
| In vitro | Zingeroneis similar in chemical structure to other flavor chemicals such as vanillin and eugenol. It is used as a flavor additive in spice oils and in perfumery to introduce spicy aromas. Fresh ginger does not contain vanillylacetone; cooking the ginger transforms gingerol, which is present, into Zingeronethrough a retro-aldol reaction. Zingeroneis likely the active constituent responsible for the antidiarrheal efficacy of ginger. [1] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 36 mg/mL (185.35 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (10.3 mM), Sonication is recommended.
H2O : 10 mg/mL (51.49 mM), Heating is recommended.
DMSO : 50 mg/mL (257.43 mM), Sonication is recommended.
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| Keywords | Zingerone | Nuclear factor-κB | Nuclear factor-kappaB | NSC-15335 | NSC15335 | NF-κB | NFκB | NF-kB | NFkB | Inhibitor | inhibit |
| Inhibitors Related | Undecane | Sodium propionate | Ethyl palmitate | Kojic acid | Uridine | Fumaric acid | Methylamine HCl | 1,4-Naphthoquinone | Glucosamine | Ethyl linoleate | N,N-Dimethylacetamide | Magnesium sulfate |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Natural Product Library | Miao medicine Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library | Anti-Cancer Active Compound Library |
United States
