| Name | ZM323881 hydrochloride |
| Description | ZM323881 hydrochloride (ZM 323881 HCl) is a potent and selective VEGFR2 inhibitor. |
| In vivo | At concentrations below 1 μM, ZM323881 inhibits the proliferation of neural stem cells stimulated by VEGF in a dose-dependent manner. It impedes the activation of extracellular signal-regulated kinase, p38, Akt, and endothelial nitric oxide synthase (eNOS) through VEGF blockade at 1 μM, without suppressing the expression of the VEGFR-1 specific ligand, placental growth factor (PlGF), in human aortic endothelial cells (HAECs). Additionally, 1 μM ZM323881 disrupts VEGF-induced membrane extension, cell migration, and tube formation in HAECs and reverses the phosphorylation of CrkII and its SRC homology 2 domain-binding protein p130Cas, key in regulating endothelial cell migration. ZM323881 inhibits the proliferation of HUVEC cells induced by VEGF-A, EGF, and bFGF, with IC50 values of 8 nM, 1.9 μM, and 1.6 μM respectively. At 10 nM, ZM323881 eradicates the increase in vascular permeability mediated by VEGF-A in the mesenteric microvasculature of male leopards. Furthermore, 10 nM ZM323881 completely obstructs VEGF-induced promoter activity and Hif-1α protein accumulation in VEGF-stimulated SCC-9 cells. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 40 mg/mL (97.12 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.86 mM), Sonication is recommended.
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| Keywords | ZM-323881 Hydrochloride | ZM323881 hydrochloride | ZM-323881 | ZM323881 | ZM 323881 Hydrochloride | ZM 323881 | VEGFR2 | VEGFR1 | VEGFR | Vascular endothelial growth factor receptor | PDGFRβ | Inhibitor | inhibit | FGFR1 | EGFR |
| Inhibitors Related | Ribociclib | Amlexanox | Sorafenib | Ferulic Acid | Nintedanib esylate | Erlotinib | Neratinib | Chloramphenicol | Formononetin | Gefitinib | Lenvatinib | Pazopanib |
| Related Compound Libraries | Highly Selective Inhibitor Library | Osteogenesis Compound Library | Apoptosis Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Hematonosis Compound Library | Anti-Breast Cancer Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |
United States
