| Name | ZZL-7 |
| Description | ZZL-7 is a fast-onset antidepressant agent that disrupts the interaction between neuronal nitric oxide synthase (nNOS) and the serotonin transporter (SERT) in the dorsal raphe nucleus (DRN). It easily crosses the blood-brain barrier and has research value in major depressive disorder (MDD). |
| In vitro | In 293T cells transfected with nNOS and SERT, ZZL-7 (1.0 μM; 2 h) significantly decreases the SERT-nNOS complex level[1]. |
| In vivo | ZZL-7 (10 mg/kg; intraperitoneal administration) reverses chronic unpredictable mild stress (CMS)-induced depressions behaviors 2 hours after treatment. ZZL-7 (10, 20, and 40 mg/kg; Intragastric administration; once) produces antidepressant-like behaviors dose dependently 2 hours after treatment. ZZL-7 (10 mg/kg, intraperitoneally) causes significantly increases firing frequency of serotonergic neurons 2 hours after treatment in vivo electrophysiology in SERT-Cre mice. In wild-type mice, ZZL-7 reduces immobility time[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 12 mg/mL (49.12 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (8.19 mM), Sonication is recommended.
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| Keywords | ZZL-7 | ZZL7 | ZZL 7 | SerotoninTransporter | Serotonin Transporter |
| Inhibitors Related | Dapoxetine hydrochloride | Fluvoxamine maleate | Venlafaxine hydrochloride | Desvenlafaxine succinate hydrate | 1-(2-Methoxyphenyl)piperazine hydrochloride | Amitriptyline hydrochloride | Vortioxetine hydrobromide | Trazodone hydrochloride | Fluoxetine hydrochloride | Paroxetine hydrochloride | Cinchonidine | Paroxetine |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Neuronal Signaling Compound Library | Antidepressant Compound Library | Membrane Protein-targeted Compound Library | CNS-Penetrant Compound Library | PPI Inhibitor Library | Bioactive Compounds Library Max |
United States
