普健生物（武汉）科技有限公司

链接：https://www.abinscience.cn/product/40/3812.html

名称：Anti-Human CD331/FGFR1 Antibody (A08) 

Accession号：P11362

货号：HY105107

种属反应性：Human

宿主：Mouse

形式：Liquid

纯度：>95% as determined by SDS-PAGE.

克隆性：Monoclonal

同种型：IgG2a, kappa

应用：FCM

靶点：FLT2,  HBGFR, BFGFR, FGFR-1, CEK, Fibroblast growth factor receptor 1, FGFR1,  bFGF-R-1, Fms-like tyrosine kinase 2, FGFBR, FLT-2, CD331, Basic  fibroblast growth factor receptor 1, FLG, Proto-oncogene c-Fgr, N-sam

用途范围：仅用于科研

储存：Use  a manual defrost freezer and avoid repeated freeze-thaw cycles. Store  at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C  long term.

产品介绍：Anti-Human  CD331/FGFR1 Antibody (A08) 是艾必赛 (abinScience)  推出的一款高性能小鼠源单克隆抗体。该抗体特异性靶向人成纤维细胞生长因子受体1 (Fibroblast Growth Factor  Receptor 1)，也称为 CD331 或 FGFR1。FGFR1  是一种关键的酪氨酸激酶受体，在调控胚胎发育、细胞增殖、分化与迁移等基本生物学过程中扮演着核心角色，是研究骨骼发育、肿瘤发生及代谢性疾病的重要靶点。本品克隆号为  A08，同种型为 IgG1, kappa，通过 Protein A/G 方法从细胞培养上清中纯化，经SDS-PAGE检测纯度高于  95%，确保了产品的高纯度与批间一致性。该抗体已通过流式细胞术 (FCM) 严格验证。实验数据显示，在 MCF7  细胞中，本品能产生强烈的特异性荧光信号，与同型对照相比区分显著，适用于对人源细胞或组织样本中 CD331/FGFR1  蛋白的表达进行精准检测与分析。

产品购买联系方式：027-87433958/17302791434

邮箱：info@abinscience.com

参考文献：

1. FGFR1-related congenital hypogonadotropic hypogonadism: a case report and literature review. PMID: 41108094

2. FGFR1 mutations in Kallmann syndrome. PMID: 20389085

3. A FGFR1 inhibitor patent review: progress since 2010. PMID: 27976968

4. FGFR1 wild-type rosette-forming glioneuronal tumours. PMID: 39167187

5. FGFR1 variants contributed to families with tooth agenesis. PMID: 37833774

6. FGFR1 fusions as a novel molecular driver in rhabdomyosarcoma. PMID: 38607246

7. Novel FGFR1 Variants Are Associated with Congenital Scoliosis. PMID: 34440300

8.  [FGFR1 and MOZ, two key genes involved in malignant hemopathies linked  to rearrangements within the chromosomal region 8p11-12]. PMID: 11174118

9. The D647N mutation of FGFR1 induces ligand-independent receptor activation. PMID: 37778450

10.  The FGFR1 Signaling Pathway Upregulates the Oncogenic Transcription  Factor FOXQ1 to Promote Breast Cancer Cell Growth. PMID: 36778115

11. Frequent FGFR1 hotspot alterations in driver-unknown low-grade glioma and mixed neuronal-glial tumors. PMID: 35018490

12.  FGFR1 governs iron homeostasis via regulating intracellular protein  degradation pathways of IRP2 in prostate cancer cells. PMID: 39154074

13. New Phenotypic Features in FGFR1-Related Osteoglophonic Dysplasia. PMID: 40260920

14. Uterine Sarcoma With FGFR1-TACC1 Gene Fusion: A Case Report and Review of the Literature. PMID: 36302190

15. Deficiency of endothelial FGFR1 signaling via upregulation of ROCK2 activity aggravated ALI/ARDS. PMID: 36969192

16.  Prognostic value of FGFR1 expression and amplification in patients with  HNSCC: A systematic review and meta-analysis. PMID: 33989301

17. The sum is greater than the FGFR1 partner. PMID: 15050910

18. Dysregulation of FGFR1 signaling in the hippocampus facilitates depressive disorder. PMID: 40813470

19.  FGFR1 copy number in breast cancer: associations with proliferation,  histopathological grade and molecular subtypes. PMID: 33753561

20. Genomic insights into the mechanisms of FGFR1 dependency in squamous cell lung cancer. PMID: 37909331

21.  FGFR1 promotes tumor immune evasion via YAP-mediated PD-L1 expression  upregulation in lung squamous cell carcinoma. PMID: 35870429

详情请咨询 abinScience 亚洲区官方子公司 —— 武汉艾必赛生物技术有限公司

官方网址：【中文】https://www.abinscience.cn

【英文】https://www.abinscience.com

武汉艾必赛生物技术有限公司成立于 2023 年，是 abinScience 在亚洲地区设立的官方全资子公司，全面负责 abinScience 品牌在亚太市场的科研试剂推广、销售及技术支持工作。

依托严格的产品研发体系和国际化的质量管理标准，武汉艾必赛与 AtaGenix、ProteoGenix 等知名品牌保持长期战略合作，现已构建起涵盖抗体、重组蛋白、工具酶、试剂盒、实验耗材在内的多品类供应体系，面向区域内科研机构、高校实验室与生物医药企业，提供稳定、高效、可信赖的产品与服务。

核心业务覆盖：
✅ 抗体产品（单抗、多抗、重组抗体等）
✅ 蛋白与多肽试剂（标签蛋白、功能蛋白等）
✅ 分子与细胞实验相关耗材
✅ 定制化研发服务（蛋白表达、抗体定制、亲和力成熟等）
✅ 科研供应链整合与项目配套支持

武汉艾必赛始终秉持“Empowering Bioscience Discovery”的理念，为亚太地区的生命科学研究持续注入高质量动能。