曲古菌素A

• 英文名称：

• TRICHOSTATIN A

• CAS号：

• 58880-19-6

• 分子式：

• C17H22N2O3

• 分子量：

• 302.37

• EINECS号：

• 611-758-2

• 熔点 

• 140-143℃

• 比旋光度 

• D20.5 +62.8° ±1.1° (c = 1.007 in ethanol)

• 密度 

• 1.139

• 折射率 

• 136 ° (C=0.3, MeOH)

• 溶解度 

• ethanol: 1 mg/mL
  

• 形态

• Off-white lyophilized solid

• 酸度系数(pKa)

• 8.93±0.23(Predicted)

• Merck 

• 14,9649

• InChIKey

• ZWGICMNKJBUOHG-RCXLNATQSA-N

Trichostatin A, also known as TSA, is a HDAC inhibitor. TSA inhibits the eukaryotic cell cycle during the beginning of the growth stage. TSA can be used to alter gene expression by interfering with the removal of acetyl groups from histones (histone deacetylases, HDAC) and therefore altering the ability of DNA transcription factors to access the DNA molecules inside chromatin. It is a member of a larger class of histone deacetylase inhibitors (HDIs or HDACIs) that have a broad spectrum of epigenetic activities. TSA inhibits HDACs 1, 3, 4, 6 and 10 with IC50 values around 20 nM.