扎伊尔埃博拉病毒 GP 蛋白兔多克隆抗体

• 中文名称

• 扎伊尔埃博拉病毒 GP 蛋白兔多克隆抗体

• 英文名字

• Rabbit polyclonal antibody to Zaire Ebolavirus GP protein

• 供应商

• Icosagen

• 产品货号

• A2-100-100

• 背景资料

• GP1 is responsible for binding to the receptors on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. Binding to CD209 and CLEC4M, which are respectively found on dendritic cells (DCs), and on endothelial cells of liver sinusoids and lymph node sinuses, facilitate infection of macrophages and endothelial cells. These interactions not only facilitate virus cell entry, but also allow capture of viral particles by DCs and subsequent transmission to susceptible cells without DCs infection (trans infection). GP2 acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.GP1,2 mediates endothelial cell activation and decreases endothelial barrier function. Mediates activation of primary macrophages. At terminal stages of the viral infection, when its expression is high, GP1,2 down-modulates the expression of various host cell surface molecules that are essential for immune surveillance and cell adhesion. Down-modulates integrins ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGAV and ITGB1. GP1,2 alters the cellular recycling of the dimer alpha-V/beta-3 via a dynamin-dependent pathway. Decrease in the host cell surface expression of various adhesion molecules may lead to cell detachment, contributing to the disruption of blood vessel integrity and hemorrhages developed during Ebola virus infection (cytotoxicity). (Ebola GP1 and 2 functions, UniProt).

• 应用类型

• ELISA, WB, IF

• 免疫原

• Ebolavirus GP protein

• 来源宿主

• 兔

• 反应性

• Zaire Ebolavirus GP protein

• 保存建议

• Store at +4°C upon receipt. As product is (NH4)2SO4 precipitate, mix well by pipetting or vortexing prior use.

• 其他

• Icosagen AS成立于1999年，总部位于爱沙尼亚，提供一系列现成产品，如抗体、蛋白质、ELISA试剂盒等，以及天然橡胶过敏原检测和食品质量控制领域的质量控制服务。产品涵盖的应用领域有：神经生物学，病毒学，心脏标志物，细胞因子，炎症，过敏原等。Icosagen提供用于诊断和研究的重组抗体和抗原。Icosagen将现代重组技术和20年的制药经验引入诊断领域，以开发和生产高质量的试剂。利用Icosagen的专利系列，开发和生产高亲和力和特异性的单克隆和多克隆抗体。Icosagen已通过ISO 9001:2015认证，并遵循GLP指南。

湖北艾普蒂生物工程有限公司（简称：艾普蒂）由在国内科研试剂领域有着十几年从业经验的专业技术团队和企业管理团队组建而成，专门从事以抗体、蛋白、细胞、化学品为核心的试剂产品研发与销售。

我们长期聚焦于生命科学、生物医药、医疗诊断、分析检测等领域，专注于为生命科学和生物技术领域的客户提供优质的产品和技术服务。公司整合了国内外100多家行业知名品牌，提供生命科学 试剂、供应链服务等，为更多的生命科学科研工作者提供 专业、全面、安全、快捷的产品和服务。产品覆盖 基因、蛋白、细胞、组织、动物等水平的各种研究。

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