aladdin 阿拉丁 R137370 D-AP5,NMDA谷氨酸位点拮抗剂 79055-68-8 98%

中文名：D-AP5,NMDA谷氨酸位点拮抗剂

英文名：(R)-(-)-2-Amino-5-phosphonopentanoic acid

纯度：Moligand™，≥98%

货号：R137370

Cas号：79055-68-8

存储温度：避光,-20°C储存

运输条件：超低温运输

产品介绍：

D-AP5 is a selective antagonist of the NMDA receptor. D(-)-2-Amino-5-phosphonovaleric acid is described to antagonize amino acid-induced synaptic excitations, blocking L-aspartate and dorsal root-evoked spinal neuron excitation, without affecting cholinergic excitation induced by exogenous acetylcholine administration. Evoked electrical activity of neurons is suppressed by D(-)-2-Amino-5-phosphonovaleric acid antagonism of motoneuronal depolarizations at the NMDAR. The (+)-stereoisomer of D(-)-2-Amino-5-phosphonovaleric acid demonstrates considerably diminished NMDAR activity as compared to this (-)-isomer.A selective antagonist of the NMDA receptor.

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