aladdin 阿拉丁 D127636 度鲁特韦 (GSK1349572) 1051375-16-6 ≥99%

中文名：度鲁特韦 (GSK1349572)

英文名：Dolutegravir (GSK1349572)

中文别名：度鲁特韦

英文别名：GSK1349572|DOLUTEGRAVIR [VANDF]|GSK 1349572|HSDB 8152|Tivicay (TN)|2H-Pyrido(1',2':4,5)pyrazino(2,1-b)(1,3)oxazine-9-carboxamide, N-((2,4-difluorophenyl)methyl)-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS)|SCHEMBL82071|Z2235801952|FT-

纯度：≥99%

货号：D127636

包装：10mg、50mg、5mg

Cas号：1051375-16-6

存储温度：-20°C储存

产品介绍：

S/GSK1349572 inhibits recombinant HIV-1 integrase-catalyzed strand transfer in vitro. S/GSK1349572 potently inhibits HIV replication in cells infected with a self-inactivating PHIV lentiviral vector, such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4. S/GSK1349572 exhibits potent activity against five different nonnucleoside reverse transcription inhibitor--resistant or nucleoside reverse transcription inhibitor--resistant viruses in vitro. S/GSK1349572 shows equivalent activity against two protease inhibitor-resistant viruses similarly to that against wild-type virus.Dolutegravir (GSK1349572)是一种HIV整合酶抑制剂，IC50为2.7 nM，适度有效作用于抗Raltegravir的显著突变体Y143R， Q148K， N155H，和G140S/Q148H。

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